Page 58 - phytochemistry II -pharmD general
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Volatile bases
Beside the above mentioned bases, Solanaceous plants contain
volatile bases e.g. choline, pyrrol, pyrollidine, pyrroline, N-methyl pyrolline, N-
methyl pyrrolidine and trimethylamine.
Esterifying acids in tropane alkaloids
1- Tropic acid: (α -phenyl- β-hydroxy-propionic acid).
▪ The optically active l-form occurs in hyoscyamine and hyoscine.
▪ The optically inactive (racemic mixture) dl-form occurs in atropine.
2- Atropic acid in apoatropine.
COOH COOH
C CH2O H C CH2O H
H H
(-) - Tropic acid (+) - T ropic acid
COOH
Atropic acid
A. Atropine
Occurrence
Atropine is obtained from Atropa belladonna, Hyoscyamus, Datura and
Duboisia species.
Me
N
H OH
H
O
O
Atropine (dl (±) hyoscyamine)
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