Page 154 - COMMUNITY PHARMACY PRACTICE
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02/04/2024

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     Risk Factors/precipitating factors for Developing
                  Asthma (Asthma triggers)

                          • Genetic characteristics
                          • Occupational exposures
                          • Environmental exposures

         Allergy              Air         Viral                Stress and
        Cold air          pollutants  respiratory               emotions
       /exercise          Food and    infections
                                       Tobacco                    Drug-
312                          food                               induced?
                          additives     smoke

                                                               313

     Drug induced Asthma

          Predictable             Unpredictable                Others
     brochoconstriction:

     • beta blockers              • Aspirin and other non-     • Carbemazepine
     • (used in the management      steroidal drugs (NSAIDs)
                                                               • Parenteral drugs:
       of hypertension, cardiac   • (+ (COX) -2 inhibitors)      penicillin, iron dextran
       disorders, migraine and      used for arthritis and       complex, hydrocortisone,
       glaucoma)                    inflammatory disorders.      ipratropium bromide,
     • cholinergic agents                                        aminophylline, N-acetyl
                                  • Symptoms:Flushing +          cysteine
       • (e.g. carbachol,           rhinorrhoea, often within
          pilocarpine)              a few min-1 hr after       • preservatives such as
                                    administration.              bisulfites, metabisulfites
     • cholinesterase inhibitors                                 and benzalkonium
       • (e.g. pyridostygmine).                                  chloride.

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