Page 28 - Pharmaceutics III_ 02-06-01304_Fall 2025_ Pharm D_Electronic book

1. If oil is used → dissolve in volatile solvent and spray on granules.
2. If spray is used → mix with powder or granules before lubrication.

II-4. Sweetening Agents
Added to effervescent and chewable tablets when natural sugars (sucrose, mannitol, lactose,
dextrose) are absent.
Examples:

• Aspartame (180× sweeter than sucrose)
• Saccharin (500× sweeter)
• Cyclamates

II-5. Adsorbents
Substances that carry large amounts of liquid without swelling.
Example:
Silicone dioxide — can carry liquid up to 50% of its own weight.
Used when formulation contains:

• Oils (e.g., multivitamins)
• Liquid extracts
• Hygroscopic ingredients
Types
• Silicone dioxide
• Magnesium silicate
• Magnesium oxide
• Clays (e.g., Kaolin)
Method of Addition
Mix hygroscopic ingredients with adsorbent first, then incorporate into powder blend.

Powder Properties Before Compression
Before perfect tablets can form, powders must have:

1. Good flow: Ensures uniform die filling → consistent tablet weight.
2. Good compressibility: Upon compression, particles deform:

27