Page 31 - Pharmaceutics III_ 02-06-01304_Fall 2025_ Pharm D_Electronic book
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Disadvantages:
• Produces more dust.
• May cause weight variation.
• Granules have poorer flowability compared with wet granulation.
II - Direct compression:
Used for materials that possess excellent flow and compressibility.
Materials suitable for direct compression:
• Spray dried lactose
• Microcrystalline cellulose (Avicel)
• Anhydrous lactose
• Dicalcium phosphate dihydrate
Advantages:
• Fewer processing steps.
• Faster and cheaper.
• No moisture or heat involved.
Disadvantages:
• Limited number of excipients suitable.
• Segregation of drug and excipient may occur.
Tablet Coating:
It's the process of covering the surface of a tablet with a layer of coating material.
Objectives of coating:
1. Mask taste and odor of drug.
2. Protect the drug from air, light, and moisture.
3. Improve appearance.
4. Reduce dusting.
5. Control drug release.
Types of coating:
1. Sugar coating
2. Film coating
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