Page 40 - Pharmaceutics III_ 02-06-01304_Fall 2025_ Pharm D_Electronic book

D. Tablets for solution or dispersion:
1. Effervescent tablets:
o Contain acid (citric or tartaric) and carbonate or bicarbonate that release CO₂
when in contact with water.
o Rapid disintegration and improved taste.
o Should be stored in moisture-proof containers.
2. Soluble tablets:
o Completely dissolve in water before administration.
o Used for pediatric and elderly patients.
3. Dispensing tablets:
o High potency ingredients intended to be added to water to prepare solutions for
dispensing.

E. Tablets for other routes:
1. Vaginal tablets (pessaries):
o Uncoated, inserted into vagina for local effect (antiseptic, antifungal,
antibacterial).
o Prepared by compression; rapidly disintegrate in vaginal fluid.
o Example: Clotrimazole vaginal tablets.
2. Implantation tablets:
o Small, sterile, cylindrical tablets inserted subcutaneously or intramuscularly for
prolonged drug release.
o Example: Testosterone implants.

F. Orally Disintegrating Tablets (ODTs):
• Disintegrate rapidly (within 30 seconds) on the tongue without need of water.
• Beneficial for pediatric, geriatric, or dysphagic patients.
• Prepared by freeze-drying (lyophilization) or direct compression using
superdisintegrants.
• Examples: Ondansetron ODT, Cetirizine ODT.

Excipients used in ODTs:
• Superdisintegrants: Crospovidone, Croscarmellose sodium, Sodium starch glycolate.

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