Page 45 - Pharmaceutics III_ 02-06-01304_Fall 2025_ Pharm D_Electronic book
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o Inkjet or pad printing (using edible ink).
• Printed tablets must undergo stability testing to ensure ink does not affect quality.
Tablet Defects (Detailed):
1. Capping:
Separation of top or bottom crown from the body.
Causes:
• Air entrapment.
• Worn punches/dies.
• Too dry granules.
• Excess lubricant.
Remedy:
• Modify granulation moisture.
• Use tapered dies.
• Reduce speed.
2. Lamination:
Splitting of tablet into two or more layers.
Causes:
• Over-compression.
• Too much binder.
Remedy:
• Adjust compression.
• Optimize binder concentration.
3. Chipping:
Breaking at tablet edges.
Causes:
• Poor punch alignment.
• Worn dies.
• Rapid ejection.
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