Page 46 - Pharmaceutics III_ 02-06-01304_Fall 2025_ Pharm D_Electronic book

4. Cracking:
Fine cracks on tablet surface.
Causes:

• Rapid expansion after compression.
• Large tablet size.
• Low moisture content.

5. Picking and Sticking:
Adhesion of granules to punch surface.
Causes:

• Moist granules.
• Excess binder or heat-sensitive ingredients.

Remedy:
• Dry granules properly.
• Polish punches.
• Add lubricant or antiadherent (talc).

6. Mottling:
Uneven color distribution.
Causes:

• Migration of dye during drying.
• Light reflection from ingredients.

Remedy:
• Use insoluble colors or lake pigments.
• Control drying rate.

7. Double Impression:
Printing appears twice on the tablet.
Causes:

• Free rotation of punch with embossing.
Remedy:

• Lock upper punch key to prevent rotation.

8. Weight Variation:
Unequal tablet weights due to non-uniform flow or poor mixing.
Remedy:

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