Page 51 - Pharmaceutics III_ 02-06-01304_Fall 2025_ Pharm D_Electronic book
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5. Trimming: edges cut to uniform length.
6. Joining: body and cap fitted together.
Sizes of Hard Gelatin Capsules:
Size Capacity (mg, average)
000 950
00 650
0 450
1 300
2 250
3 200
4 150
5 100
Filling of Hard Gelatin Capsules:
Filling Materials:
• Powder blends or granules.
• Pellets (multi-particulate systems).
• Tablets (capsule-in-tablet).
• Non-aqueous liquids or semisolids (using plugs).
Requirements for powders:
• Good flow and compressibility.
• Uniform particle size.
• Non-hygroscopic and non-reactive.
Methods of Filling:
1. Hand filling (manual method):
o Capsule bodies placed in loading tray.
o Powder poured and compacted manually.
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