Page 48 - Pharmaceutics III_ 02-06-01304_Fall 2025_ Pharm D_Electronic book
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Cleaning and Maintenance of Tablet Equipment:
• Regular cleaning to prevent cross-contamination.
• Lubrication of moving parts.
• Periodic calibration and inspection of punches/dies.
Tablet Quality Assurance:
In-process controls:
• Weight variation
• Hardness
• Thickness
• Disintegration
Finished product testing:
• Assay
• Dissolution
• Stability
Tablet Packaging Defects:
1. Moisture absorption → soft tablets.
2. Breakage due to poor handling.
3. Label mix-up.
4. Improper sealing → contamination.
Good Manufacturing Practices (GMP):
• Proper documentation.
• Training of personnel.
• Calibration and maintenance of equipment.
• Environmental control.
• Process validation.
Tablet Storage Conditions:
• Cool, dry place below 30°C.
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