Page 144 - Pharmacognosy-I (02-06-06-102)

CONTRAINDICATIONS

Quinine should not be used during pregnancy.

PRECAUTIONS AND ADVERSE REACTIONS
General: Sensitization to Quinine and Quinidine have been

observed (eczema, itching). Even at therapeutic dosages, an
enhanced pseudohemophiliac effect can occur through the
triggering of thrombocytopenia.

Drug Interactions: Because of the possibility of thrombocytopenia,

care must be taken when Quinine preparations areadministered along
with other drugs that are known to
precipitate thrombocytopenia.

OVERDOSAGE

In cases of overdose (more than 3 gm Quinine) or of longterm
administration of the drug or its alkaloids, nausea, headache, fall of body
temperature, intravascular hemolysis, cardiac arrhythmias, buzzing in the
ears,hearing and visual disorders (all the way to completedeafness and
blindness) may occur. Death comes with
dosages of 10 to 15 gm of Quinine through heart failure and
asphyxiation. Following gastric lavage, the symptomatic
therapy for acute poisonings includes atropine for bradycardia
and phenytoin in the presence of tachycardic heart
rhythm disorders.

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