Page 260 - Applied Pharmacognosy

Racemic drug mixture may display different pharmacological effects for the
individual enantiomers

e.g. teratogenic. R(+) antiemetic
•S(-) Thalidomide

•Naproxen analgesic, non analgesic
•Ethambutol #arthritis pain liver poisoning,
#tuberculosis blindness

•Amphetamine
- D-isomer is strong CNS stimulant
- L-isomer stimulate peripheral nervous system,used as nasal

inhaler & no central stimulation

-Pharmaceutical industry has become interested in chromatographic
resolution of enantiomers as a mean of producing optically pure dosage

forms

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