Page 233 - Pharmaceutics IV (02-06-01305)
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Formulation Development
Dosage form
Factors affecting drug absorption
Formulation considerations
Physiological
Pharmaceutical
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Physiological effects
- Drug metabolism in the respiratory tract &
reduction of systemic effect
- Protein binding
- Mucociliary transport causing increased or
decreased drug residence time
• Local toxic effects of the drug
Eg., edema, cell injury, or altered tissue defenses
• Local or systemic effects of propellants, 42
preservatives, or carriers
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