Page 236 - Pharmaceutics IV (02-06-01305)
P. 236
30/03/2024
2. Effect of molecular size.....
• With the assistance of absorption enhancer, a good
bioavailability can be extended to a molecular
weight of at least 6000 Daltons
• Absorption enhancers: Polyacrylic acid
Sodium Glycocholate
Sodium Deoxycholate
Polysorbate 80 etc.
Dr ALyaa Ramadan, AU 47
47
3. Effect of solution pH
- Nasal absorption is pH dependent
- Absorption is higher at a pH lower than the
dissociation constant (pKa) of the molecule
- Absorption is lower as the pH increases beyond
the dissociation constant
Dr ALyaa Ramadan, AU 48
48
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