Page 248 - Pharmaceutics IV (02-06-01305)

3/30/24

Advantages of local drug

delivery to the lung

• The dose of the drug required for local treatment can be
significantly reduced.

– For example, orally administered salbutamol at 2–4 mg of dose is
therapeutically equivalent to 100–200 μg of salbutamol administered
directly into the lung. (>100 times reduction in dose)

• SO less systemic drug side effects
• Escape drug metabolism
• High local concentrations
• Rapid clinical response.
• The possibility of simultaneous oxygen therapy and

pharmacotherapy

Prof Alyaa Ramadan, ceutics, AU

3

Barriers to pulmonary drug
delivery

• Airway geometry

• Localized high humidity

• Mucociliary clearance

• Alveolar Macrophages.

Prof Alyaa Ramadan, ceutics, AU

4

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