Page 253 - Pharmaceutics IV (02-06-01305)

3/30/24

Which form? intended use?

For instance, an aerosol for inhalation therapy, as in the treatment of asthma or
emphysema, must present particles in the form of a fine liquid mist or as finely
divided solid particles..
Particles less than 6 μm will reach the respiratory bronchioles, and those less than
2μm will reach the alveolar ducts and alveoli .

By contrast, the particle size for a dermatologic spray intended for deposition on the
skin is coarser and generally less critical to the therapeutic efficacy of the product.
Some dermatologic aerosols present the medication in the form of a powder, a wet
spray, a stream of liquid (usually a local anesthetic), or an ointment-like product.

Other pharmaceutical aerosols include vaginal and rectal foams.

Prof Alyaa Ramadan, ceutics, AU

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Terminology (Aerosols sounds
like …)

What is aerosil? What is aerosol OT?

• Fumed silica product • anionic surfactant (Sodium
composed of pure silicon dioctyl sulfosuccinate) has an
dioxide give free flowing excellent wetting agent and
to powder material and it emulsifier,
give thickening effect by
dispensing into liquid • Mold Release Agent for
material (filler in tablets) Methacrylic Polymers
(PMMA), for cleaning
paintings and laboratory
cleaning operations, could be
added to water soluble pastes,
increases their penetration and
adhesion.
Prof Alyaa Ramadan, ceutics, AU

14

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