Page 254 - Pharmaceutics IV (02-06-01305)
P. 254
3/30/24
ADVANTAGES OF THE
AEROSOL DOSAGE FORM
By virtue of its hermetic character, so no contamination and protect the
drug from air, moistureand light and thus suitable for unstable drugs. E.g
epinephrine.
If the product is packaged under aseptic conditions, sterility may also be
maintained during the shelf life of the product.
Alternative to creams and lotions in case of burns as these are
painful.(doesn’t require finger application) and The rapid volatilization of
the propellant also provides a cooling, refreshing effect. Aerosol
application is a clean process, requiring little or no washup by the user.
Prof Alyaa Ramadan, ceutics, AU
15
THE AEROSOL PRINCIPLE
An aerosol formulation consists usually of two component
parts: the product concentrate and the propellant
The product concentrate is the active ingredient of the aerosol
combined with the required adjuncts, such as antioxidants,
surface- active agents, and solvents to prepare a stable and
efficacious product.
When the propellant is a liquefied gas or a The propellant is either
mixture of liquefied gases, it frequently serves liquified or compressed
the dual role of propellant and solvent or gas
vehicle for the product concentrate.
Prof Alyaa Ramadan, ceutics, AU
16
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