Page 249 - Pharmaceutics IV (02-06-01305)

3/30/24

Systemic drug delivery
through the lung

• Sufficient drug must be deposited in the alveolar
cavity, so that adequate amount of a drug would
be absorbed into the systemic circulation to
elicit therapeutic efficacy.

• Traditional inhalation devices deposited only
~10%–15% of the inhaled drug in the lung.

Prof Alyaa Ramadan, ceutics, AU

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AEROSOLS

• Aerosols are colloidal dispersion or suspensions of a
solid or a liquid in a gas (e.g., air)

• It is a specialized dosage forms used for pulmonary drug
delivery.

• Pharmaceutical aerosols are mostly pressurized dosage
forms that upon actuation emit a fine dispersion of liquid
and/or solid materials containing one or more active
ingredients in a gaseous medium.

Prof Alyaa Ramadan, ceutics, AU

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