Page 256 - Pharmaceutics IV (02-06-01305)
P. 256

3/30/24

    TypesTypoesfof pProperlloansp? ellant?

                                       HC                                                              Flammable,
                                (Hydrocarbon)                                                          immiscible

                                                                                                        with H2O

                Liquefied        CFHC                                                                        Non-
                  gases         (Freon)                                                                 flammable,

                                                                                                       deplete ozone

    Propellant                             HFA                                                             Ozone
                                (Hydrofluoroalkane)                                                    friendly, low

                                                                                                             v.p

                Compressed      N2O ,CO2                                                               More
                     gases          ,N2                                                                new
                                                                                                       liquified
      Does it differ in the design of aerosol                                                          gases?
    container when the propellant is CFCs or                                                           bonus

                           HCs?

                                                 Prof Alyaa Ramadan, ceutics, AU

19

    Hazards of Freon , CFHC

       To the Patient               Environment
                                Ozone depletion So
     • Irritation of pharynx
       and bronchi if inhaled        increase amount of
                                    ultraviolet radiation
         (other propellant as       reaching the earth so
       well but lesser extent)   increase incidence of skin
    • Sometimes cardiotoxic
                                            cancer
            (repeated use)!

                                                                      Prof Alyaa Ramadan, ceutics, AU

20

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