Page 53 - Pharmaceutics IV (02-06-01305)
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Parenterals: Dosage forms
Injectable emulsion
• For water-insoluble drugs.
• Formulation concept & method:
Formulation options are severely restricted through a very limited
selection of stabilizers and emulsifiers (sterilization, toxicity, …) .
• Route:
➢ o/w emulsions can be administered via IM (depot injections) or IV
(total parenteral nutrition; TPN) routes.
➢ w/o emulsions can’t be administered via IV to avoid oil embolism.
99
Parenterals: Dosage forms
Injectable emulsion
• Requirements:
➢ No evidence of phase separation for the emulsions
➢ Droplet size must be controlled and is usually less than 3 μm in
diameter to prevent oil embolisms forming in the blood-stream.
100 50
Salma E. EL-Habashy
