Page 55 - Pharmaceutics IV (02-06-01305)

Parenterals: Dosage forms

• Physicochemical drug properties and therapeutic considerations
(Drug solubility and stability)

• Route of administration:
➢ IV: only aqueous or blood-miscible solutions and o/w emulsions
➢ IM: aqueous or oleaginous solutions or suspensions

Considerations for dosage form selection

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Parenterals: Dosage forms

• Desired onset and duration of action
➢ Drugs that are more soluble in body fluids show the most rapid
absorption and onset of action.
➢ Sometimes, long action is desired to reduce the frequency of
injections (depot preparations).
➢ Rapidity of onset: solutions > suspensions & aqueous preparations
> oleaginous preparations

Considerations for dosage form selection

104

Salma E. EL-Habashy 52