Page 147 - Pharm.Org.Chem-I 02-06-05-101
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Hoffmann Rule
(Less substituted alkene predominates
when steric hindrance exists)
Unimolecular Elimination Reaction (E1)
slow fast
Carbocation + B-H
intermediate
Properties of E1:
1. Two-step.
2. Nonstereospecific.
3. Reaction rate = k [RX].
Factors affecting E1
1. Requires weak bases: H2O, ROH.
2. Polar protic solvent.
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