Page 279 - Biochemistry PharmD General

Inhibitors of heme synthesis: The following
substances inhibit heme synthesis

• Succinylacetone (SA) is an inhibitor of heme synthesis
that acts on the enzyme aminolevulinic acid
dehydratase.

• N-methyl mesoporphyrin IX blocks iron insertion into
protoporphyrin IX and thus acts as an inhibitor of
heme synthesis.

• Isonicotinic acid hydrazide (INH) is an inhibitor of 6-
aminolevulinic acid synthase.

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