Page 27 - Dosage 1-part2 -ebook_Neat

30/10/2025, 00:02 Pharmaceutical Solutions & Sterile Dosage Forms

Method of solution preparation

Manufacturing Tips & Hints

Oral solutions

Solution pH is usually 7.0, although a range of pH 2–9 can be tolerated.
For convenience, the dose is usually in multiples of 5 mL, and the patient is given a 5 mL
spoon with the solution.
When smaller volumes are required, oral syringes are used.
Solutions have a higher viscosity than water.
Viscosity should be appropriate for palatability and pourability.
They are swallowed where the drug may exert a local effect on the GIT or be absorbed into
the blood and exert a systemic action.
They are aqueous formulations to be acceptable to patient. Flavoring, coloring and
sweetening agents are added to enhance their appearance and taste.

Oral solutions

Syrups

Syrups are highly concentrated aqueous solutions of sugar or a sugar substitute with or without
flavoring agents and therapeutics agents.

Traditionally syrups are composed of sucrose (60-80 %) and purified water.

Example:

Simple Syrup BP: Sucrose in purified water 66.7%(w/w)
Simple Syrup USP: Sucrose in purified water 85%(w/w)

NOTE: Both can be used as such as vehicle.

file:///C:/Users/sara talaat/Downloads/solutions and sterile sols.HTML 24/77