Page 28 - Dosage 1-part2 -ebook_Neat

30/10/2025, 00:02 Pharmaceutical Solutions & Sterile Dosage Forms

Due to its inherent sweetness and moderately high viscosity, the addition of other sweetening

agents and viscosity-modifying agents is not required.

The high concentration of sucrose and associated unavailability of water ensures that the
addition of preservatives is not required. (if diluted add preservative).

Syrup BP it promotes dental decay and is unsuitable for diabetic patients.

'Sugar free' syrups are obtained by replacing sucrose with hydrogenated glucose (sorbitol),
mannitol, xylitol, etc.

NOTE: Hydrogenated glucose refers to a sugar alcohol sorbitol, derived from glucose
through a process called hydrogenation.

All medicinal products designed for administration to children and to diabetic patients must be
sugar-free.

Sugar-free syrups contain sucrose substitutes (e.g. Sorbitol Solution USP, which contains 64%
w/w sorbitol) or artificial sweeteners (e.g. aspartame).

Syrup preparation

Method Description Suitable for
Heating Heat stable drugs (not
method Sucrose is dissolved in water by application of heat (but volatile or degraded by
not boiling). Water is heated to 80-85 ℃. heat)
Agitation
Sugar is added to water and intensely agitated Heat labile drugs
Percolation (magnetic stirrers on a small-scale, stainless-steel tanks
with mechanical mixers on a large scale) for prolonged More time consuming
periods to ensure complete dissolution. than heat but product
of high stability.
Water is passed repeatedly over a bed of sugar.

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