Page 115 - Pharmd general phytochemistry I-Final2024_LEUCTERS

Some Synthetic Disaccharide Derivatives
1- Sucralfate

 Sucralfate is the basic aluminum salt of the fully sulfated derivative of sucrose.

Uses:
 Treatment of peptic and duodenal ulcer.
 Sucralfate exerts its action by formation of a large complex with proteins that

adheres to the ulcer, thus building a barrier that prevents penetration of gastric
acids, pepsin and bile acid and allow healing to happen, in addition, sucralfate
suspension adsorbs bile acids and pepsin, thereby diminishing their concentrations
in the stomach.
Doses:
 1 g four times daily.
 The most frequent adverse effect is constipation.

2- Lactulose

4-O-(β-D galactpyranosyl) D-fructofuranose

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