Page 142 - Pharmd general phytochemistry I-Final2024_LEUCTERS

(2) Amiodarone

 It is a potent coronary dilator for treating angina. It is established for prophylactic control
of supraventricular and ventricular arrythmias.

Furanocoumarins (Psoralens)

 Psoralens are heterocyclic aromatic compounds derived from linear condensation of a
coumarin nucleus (benzo α-pyrone) with a furan ring.

 Natural furanocoumarins have been isolated from the plant families: Umbelliferae,
Rutaceae, Leguminosae and Moraceae.

 They are common causes of phototoxicity, in addition, they are sometimes produced as
phytoalexins by celery plant Apium gravulens after infection with fungi.

 Only linear psoralens such as psoralen, 8-methoxy psoralen, 5-methoxypsoralen and the
synthetic 4,5' -8-trimethylpsoralen (TMP) are used in photochemotherapy.

O O O OO

Coumarin Psoralen (furanocoumarin)

OCH3

O OO O OO

8-methylOpCsoHr3alen (8-MOP) 5-methoxypsoralen (5-MOP)

CH3

H3C

O OO

CH3

4,5',8-trimethylpsoralen (TMP)

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