Page 139 - Pharmd general phytochemistry I-Final2024_LEUCTERS

Uses:
 Podophyllum resin has long been used as a purgative but has largely been

replaced by less drastic drugs. It is used as a paint in the treatment of soft venereal
and other warts. Podophyllotoxin is also used for this purpose.
 It has a cytotoxic action.

Semisynthetic Podophyllotoxin Derivatives

(1) Etoposide:(4'-demethylepipodophyIlotoxine thylideneglucoside).

 Etoposide is a lignan derivative obtained semisynthetically from podophyllotoxin

and used in the treatment of small-cell lung cancer and testicular cancer as

well as lymphomas and leukemias.

H

H3C O O
O O
HO
OH
O

O

O
O

H3CO OCH3

OH
Etoposide

(2) Teniposide: (4' -demethylepipodophyllotoxin-thenylidene glucoside).

 Teniposide has similar anticancer properties and is used principally in the

treatment of pediatric neuroblastoma, lymphocytic leukaemia and brain

tumors in children. H

O O
O O
HO
S OH

O O
O
O

H3CO OCH3
Teniposide OH
Cynarin

 Cynarin is 1,3-dicaffeoylquinic acid (diester).
 Source: Leaves of artichoke, Cynara scolymus, Family Compositae.
 Actions and Uses:

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