Page 136 - Pharmd general phytochemistry I-Final2024_LEUCTERS

OH OH

HO 11 12 13 COOMe HO O COOCH3
15 OR
10 O H O
1 OR
O 2
HO 2 10 8 15
3
3 57 16 16
4 HO
6O O OO
HH 6O

Bruceolide, R= H O Bruceantin, R= HC
Bruceantinol, R= C 1' O

2' 3'

4' OCOCH3 Bruceantarin, R= C

 Class II Bruceolides which lack ester group at C-15, e.g. Bruceine D and E have
significant antimalarial activity, but no cytotoxicity action. Similar to class I, they
have a C-8 hydroxy methyl engaged in an ether function with C-13.

OH OH

HO HO
OH
O O OH OH O

OH HO OH

OH

OO OO

Bruceine D Bruceine E

Cucurbitacins

 They are tetracyclic triterpenoids which are of interest because of their cytotoxic

and antitumor properties.
 They mainly occur in the family Cucurbitaceae, as well as other families such as

Euphorbiaceae, Cruciferae and Scrophulariaceae.

Colocynth

 Colocynth is the dried pulp (endocarp) of the fruits of Citrullus colocynthis, Family
Cucurbitaceae.

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