Page 74 - phytochemistry I - PharmD Clinical

2.1.Terpene Alcohols:
Methods for separation of Terpenes alcohols:
Most terpene alcohols are conveniently separated from volatile oils via
their crystalline additive products, which is very useful for the
identification, separation and purification of the alcohols:

1- Calcium chloride addition products:
Primary alcohols, among them geraniol, cinnamyl alcohol, benzyl alcohol
and butyl alcohol form complex crystalline salts when shaken with
powered anhydrous calcium chloride in absolute ether or in benzene. The
original alcohol is easily, regenerated by the addition of water,

1 ry Powdered anhydrous CaClC2 rystalline
complex
alcohol Water salt

This addition product is formed with geraniol, but neither with nerol nor
citronellol. Thus geraniol addition product is the most important one, since
it affords a means of separating this alcohol from similar primary alcohols;
nerol and citronellol.

2- Formation of esters:
Certain esters are useful for the isolation, purification as well as
identification of alcohols such as:

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