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Level two – Semester 4 - PharmD      Biochemistry-II PB-403 (Practical course)     2024/2025


                                Serum and urine glucose level



                    In normal conditions:

                   ✓  Fasting blood glucose level is 70-110 mg/dl.


                   ✓  Postprandial blood glucose level is < 140 mg/dl.


                   ✓  Absent  in  the  urine,  as  the  renal  threshold  level  is  >  180  mg/dl  in

                       normal condition.


                         Sources of blood glucose:                    Fates of blood glucose:

                       1. Dietary carbohydrate.                     1.  Oxidation

                       2. Glycogenolysis                            2.  Glycogenesis

                       3. Gluconeogenesis                           3.  Lipogenesis



                     Examples of physiological changes in serum glucose concentration

                        Increased fasting glucose                   Decreased fasting glucose


                             concentration in:                           concentration in:

                                                              Normal pregnancy:

                                                              (mild hypoglycemia).

                                                              Severe  hypoglycemia  occurs  in
                    Due to the increased adrenaline
                                                              normal  neonates  born  to  diabetic
                         level in the circulation:
                                                              mothers.
                     ❖  Hard physical activity.
                                                              Within 2-4 hours postnatally, blood
                     ❖  Strong emotions, e.g., fear.
                                                              glucose  falls  to  the  lowest  level,

                                                              returning  to  the  birth  value  in  3-5

                                                              days.













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