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Level two – Semester 4 - PharmD Biochemistry-II PB-403 (Practical course) 2024/2025
1. Hyperglycemia & Glucosuria
Characters 2. Transient blood glucose level returns to normal
after delivery.
Differential diagnosis:
Diabetes type Blood glucose Renal glucose
Diabetes mellitus Increased Present
Diabetes insipidus Normal Absent
Renal Diabetes Normal Present
Case study
A 53-year-old male presented with a several-month history of polyuria
and polydipsia. He also had a constant thirst and had to get up more than
4 times at night to void urine. He had no significant findings on physical
examination. He is not on any regular medication. An MRI scan revealed
a large thin-walled complex cyst arising from his hypothalamus.
Laboratory data were as follows:
Serum
Test Patient Reference range
BUN 14 mg/dl (7-20 mg/dl)
Creatinine 0.9 mg/dl (0.6-1.2 mg/dl)
Sodium 156 mmol/l (135-145 mmol/l)
Potassium 4.7 mmol/l (3.5-5 mmol/l)
Serum osmolality 320 mOsm/kg (275-300 mOsm/kg)
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