Page 76 - Practical Handout bio 2 mnu 2025_Neat
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Level two – Semester 4 - PharmD Biochemistry-II PB-403 (Practical course) 2024/2025
2- Plasma Proteins
❖ They are synthesized in the liver except for gamma-globulins
which are synthesized by the lymphoreticular endothelium system
(RES) of the bone marrow.
❖ Total proteins in plasma: 6-8 g/dl.
❖ Containing more than 100 different types of proteins, the most important are:
1. Albumin: 3.5 - 5.5 g/dl – the major plasma protein (representing up to 60% of
total plasma proteins).
2. Globulin: 1.8 - 3.3 g/dl.
3. Fibrinogen: 0.2 - 0.6 g/dl.
❖ The remainder of the plasma proteins (1%) are regulatory proteins,
such as enzymes, proenzymes, and hormones.
❖ Normally, the Albumin/globulin ratio (A/G ratio) = 2/1.
Functions of plasma proteins:
1. Maintaining plasma osmotic pressure:
Plasma protein especially albumin allows solid matter to be suspended in
plasma by making osmotic pressure which antagonizes the hydrostatic
pressure.
2. Protective function: through γ-globulins.
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