Page 78 - Practical Handout bio 2 mnu 2025_Neat
P. 78
Level two – Semester 4 - PharmD Biochemistry-II PB-403 (Practical course) 2024/2025
The serum total protein test measures the total amount
of protein in serum made up of albumin, globulin, and other types of
proteins.
Hypoproteinemia
Def. Reduced plasma protein than normal (< 6 g/dl).
1. Liver disease (due to the decrease in plasma protein
synthesis except γ–globulin).
2. Renal disorders (due to excessive excretion).
3. Maldigestion.
Causes 4. Malabsorption.
5. Overhydration: (due to dilution of plasma as in excessive
intake of plasma substitutes, such as saline and glucose).
6. Severe burns because the skin is the most important extra
storage pool for albumin.
Hyperproteinemia
Def. Increased plasma protein than normal (> 8 g/dl).
Physiological Pathological conditions
dehydration
Bone marrow tumor.
Hodgkin's lymphoma.
Causes Leukemia.
Treated by increasing the
Inflammation.
fluid intake.
Any condition causing an
increase of γ-globulins.
The A/G ratio is reversed →1/2.
Differential diagnosis
Page 78 of 130
