Page 46 - Practical DF2 Corrected (2)
P. 46
Pharm D Clinical Pharmacy program 2024-2025 Level 2, Semester 2 Pharmaceutical Dosage Forms II (PT 405)
Method of preparation:
1. Melt cetyl alcohol, lanolin, and stearic acid in a large dish over a boiling
water bath, add mineral oil and heat to 75–80 °C.
2. Dissolve methyl paraben and potassium hydroxide in glycerol and water in
a beaker and heat to 75–80 °C.
3. Add gradually (2) to (1) with vigorous trituration and within 10 minutes,
remove from the bath and continue trituration until a homogenous cream is
obtained.
4. Add the perfume and color to the cream after complete cooling.
Oil phase Aqueous phase
Cetyl alcohol Dissolve
methyl
1a Lanolin paraben and 1b
Stearic acid KOH in
water
2 Melting at 2Heating atb
a 75-80°C 75-80°C
Add the heated water phase on the melted oil
3 phase with continuous trituration till semi-solid
consistency formation (cream)
45
