Page 51 - Practical DF2 Corrected (2)

Pharm D Clinical Pharmacy program 2024-2025 Level 2, Semester 2 Pharmaceutical Dosage Forms II (PT 405)

Method of preparation:

1. Melt stearic acid on a water bath, add liquid paraffin and lanolin then raise

the temperature to 75–80 °C.

2. Dissolve the alkali in water, add glycerin and heat to 75–80 °C.

3. Add (2) to (1) gradually with continuous trituration.

4. Remove from heat and continue vigorous trituration (with friction) to avoid

stearic acid crystallization.

5. After formation of the cream, transfer it to mortar then add 2 ml water by 2

ml water and stir strong and fast with pestle till the cream become fluffy,

then transfer it to container. (Note: maximum amount of water added 20 ml

and don't add excess water as the cream will be too fluid).

Oil phase Aqueous phase

1a Stearic acid Dissolve 1b
Liquid paraffin KOH in
Lanolin glycerin &
water

2 Melting at 2Heating atb
a 75-80°C 75-80°C

3 Add the heated water phase on the melted oil
phase with continuous trituration till semi-solid
consistency formation (cream)

Add 2 ml water by

4 2 ml water and stir strong and fast
with pestle till the cream become
fluffy

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