Page 358 - 2014 Printable Abstract Book
P. 358
marrow cell counts after either RI or RCBI. These data illustrate that captopril may exert its actions
differently between the two injury models (RI vs. RCBI) and suggests captopril dosing, in combination with
topical and systemic antibiotic treatments, may not be a suitable countermeasure for RCBI. This work was
supported by NIAID Grant G1B2265014. The views contained herein do not necessarily represent AFRRI,
USUHS, or the DoD.
(PS7-8) Fragmentation of 3He and 4He in elemental and composite target materials. Chiara La Tessa,
1
1
1
1
2
PhD ; Cary Zeitlin ; Michael Sivertz ; and Adam Rusek, Brookhaven National Laboratory, Upton, NY and
2
Southwest Research Institute, Durham, NH
Fragmentation of Helium in matter plays a key role both in space radioprotection and cancer
therapy with ions. Alpha particles represent about 12% of the primary galactic cosmic ray flux and are one
of the primary candidates as an alternative to protons in modern radiotherapy. Furthermore, Helium is
among the main fragmentation products from the interaction of heavier ions with matter.
The physical behavior of 4He deviates from that of other ions due to its unique nuclear structure.
Predicting the transport of Helium in matter has so far been a difficult task especially because of the lack
of experimental data to validate and improve the current models. The characterization of 3He and 4He
interaction with both elemental and composite materials has been investigated. The measurements were
performed at the NASA Space Radiation Laboratory (NSRL) in Brookhaven National Laboratory (Upton NY,
USA) and include total charge-changing cross sections at several beam energies between 90 and 1000
MeV/u as well as angular distributions and kinetic energy spectra of all charged and uncharged fragments,
from which double differential cross sections can be estimated. The results will be compared with
deterministic and Monte Carlo codes to assess their accuracy.
(PS7-10) Development of a novel biodosimetry assay based on amino acid decarboxylation. Paul J. Black,
PhD; Jeffrey S. Willey, PhD; and Michael T. Munley, PhD; Wake Forest School Medicine, Winston Salem,
NC
In the event of a radiological incident or attack on a civilian population, the proper management
of mass patient care and triage would be immensely aided by rapid and accurate assessment of individual
absorbed radiation dose. As this population is likely not to be equipped with a means of personal
dosimetry to measure total absorbed dose, the development of an accurate and rapid biodosimetric assay
capable of measuring predicable dose-dependent changes in an isolated biomarker is ideal. We describe
here our efforts into the development of a biodosimetric assay based on the decarboxylation of glutamate
(Glu) and aspartate (Asp) within serum albumin protein. Our earlier work in this study (measured with
NMR and LCMS instruments) demonstrated highly linear production of alpha-aminobutyric acid (AABA) in
0
samples of Glu irradiated at room temperature in the solid state with x-ray doses ranging from 1 x 10 to
5
1 x 10 Gy. Further efforts to detect formation of this product in small peptide and whole protein systems
in a variety of environments were not successful, most likely due to the scavenging of electron holes by
the peptide / protein backbone. The presence of this scavenging element in proximity to carboxylic amino
acid side chains likely reduces the production of AABA to levels below detectability using current LCMS
instrumentation. Future studies targeting the production of AABA in blood proteins have the potential to
be successful if detection methods are employed with a higher inherent sensitivity and specificity, such as
356 | P a g e
differently between the two injury models (RI vs. RCBI) and suggests captopril dosing, in combination with
topical and systemic antibiotic treatments, may not be a suitable countermeasure for RCBI. This work was
supported by NIAID Grant G1B2265014. The views contained herein do not necessarily represent AFRRI,
USUHS, or the DoD.
(PS7-8) Fragmentation of 3He and 4He in elemental and composite target materials. Chiara La Tessa,
1
1
1
1
2
PhD ; Cary Zeitlin ; Michael Sivertz ; and Adam Rusek, Brookhaven National Laboratory, Upton, NY and
2
Southwest Research Institute, Durham, NH
Fragmentation of Helium in matter plays a key role both in space radioprotection and cancer
therapy with ions. Alpha particles represent about 12% of the primary galactic cosmic ray flux and are one
of the primary candidates as an alternative to protons in modern radiotherapy. Furthermore, Helium is
among the main fragmentation products from the interaction of heavier ions with matter.
The physical behavior of 4He deviates from that of other ions due to its unique nuclear structure.
Predicting the transport of Helium in matter has so far been a difficult task especially because of the lack
of experimental data to validate and improve the current models. The characterization of 3He and 4He
interaction with both elemental and composite materials has been investigated. The measurements were
performed at the NASA Space Radiation Laboratory (NSRL) in Brookhaven National Laboratory (Upton NY,
USA) and include total charge-changing cross sections at several beam energies between 90 and 1000
MeV/u as well as angular distributions and kinetic energy spectra of all charged and uncharged fragments,
from which double differential cross sections can be estimated. The results will be compared with
deterministic and Monte Carlo codes to assess their accuracy.
(PS7-10) Development of a novel biodosimetry assay based on amino acid decarboxylation. Paul J. Black,
PhD; Jeffrey S. Willey, PhD; and Michael T. Munley, PhD; Wake Forest School Medicine, Winston Salem,
NC
In the event of a radiological incident or attack on a civilian population, the proper management
of mass patient care and triage would be immensely aided by rapid and accurate assessment of individual
absorbed radiation dose. As this population is likely not to be equipped with a means of personal
dosimetry to measure total absorbed dose, the development of an accurate and rapid biodosimetric assay
capable of measuring predicable dose-dependent changes in an isolated biomarker is ideal. We describe
here our efforts into the development of a biodosimetric assay based on the decarboxylation of glutamate
(Glu) and aspartate (Asp) within serum albumin protein. Our earlier work in this study (measured with
NMR and LCMS instruments) demonstrated highly linear production of alpha-aminobutyric acid (AABA) in
0
samples of Glu irradiated at room temperature in the solid state with x-ray doses ranging from 1 x 10 to
5
1 x 10 Gy. Further efforts to detect formation of this product in small peptide and whole protein systems
in a variety of environments were not successful, most likely due to the scavenging of electron holes by
the peptide / protein backbone. The presence of this scavenging element in proximity to carboxylic amino
acid side chains likely reduces the production of AABA to levels below detectability using current LCMS
instrumentation. Future studies targeting the production of AABA in blood proteins have the potential to
be successful if detection methods are employed with a higher inherent sensitivity and specificity, such as
356 | P a g e
