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Modern Geomatics Technologies and Applications

          Where     is the deviation of an attribute for feature    from its mean (   −   ),     is the spatial weight between features    and   ,
                  
                                                                           ,  
                                                                   
             is equal to the total number of features, and     is the aggregate of all the spatial weights.
                                               0

          2.2.2 Getis-Ord Gi*: Regions with the highest rates of incidence were identified as hot spot areas. Developed by Getis and Ord
          [17, 18], hot spot analysis could be beneficial in terms of studying the evidence of identifiable spatial patterns [19].
          This technique, implemented in ArcGIS software, identifies statistically significant spatial clusters of high values (hot spots)
          and low values (cold spots). In Getis-Ord Gi*, the significance and intensity of clustering is evaluated based on a confidence
          level and on output z-scores. For positive z-scores, higher z-scores reveal more intense clusters (hot spots). However, for
          negative z-scores, smaller z-score values represent more intensity of clustering of low values (cold spots) [20].

          2.2.3 Anselin Local Moran’s I: In order to obtain more information about high and low-risk zones, Anselin Local Moran’s I
          was applied. Given a set of weighted features, this technique identifies statistically significant hot spots, cold spots, and spatial
          outliers.


          2.3 Spatial statistical models
          2.3.1. Ordinary Least Squares (OLS): This global linear modeling method can be employed to examine the global relationships
          between the set of independent and dependent variables. Considering the assumption of spatial stationary, this method
          investigates the relationship between the set of explanatory and dependent variables [21, 22]. The formula of ordinary least
          squares is characterized by: [23]

                                                    =    +       +                                   (3)
                                                       0
                                                             
                                                                   
                                                    


          Where     denotes the COVID-19 incidence rate (dependent variable) at the   th location (province).    is the estimated
                  
                                                                                          0
          intercept, representing the value of    when    is 0,     signifies the vector of selected explanatory variables,    indicates the
                                                     
          vector of regression coefficients, and     is a random error term.
                                           

          2.3.2. Geographically weighted regression (GWR): Local GWR model was introduced to relax the assumption of spatial
          stationary and allowing the parameters to vary over space. Unlike global regression models, GWR detects spatial variation
          within relationships in a model and makes useful information to examine and explain spatial non-stationarity. Therefore,
          considering spatial context by GWR, this method predicts local regression parameters separately for each location [24]. The
          GWR equation is as follows: [25]

                                                    
                                          =    + ∑       +    ,    = 1,2,3, … ,   .                  (4)
                                               0
                                          
                                                            
                                                         
                                                               
                                                   =1



          Where     illustrates the COVID-19 incidence rate value at the   th province,     represents the local predicted intercept,   
                  
                                                                                                              
                                                                         0
          specifies the   th regression parameter for the   th province,     denotes the values of   th explanatory variables, and     signifies a
                                                              
                                                                                                        
          random error term.

          3.  Results and discussion
          3.1 Distribution of COVID-19 incidence rates
                 Qom, as the epicenter of the disease, had the highest incidence rate among other provinces. After Qom, provinces
          such as Tehran, Alborz, Qazvin, Markazi, Zanjan, and Lorestan were the most infected provinces with highest incidence rates
          among others in Iran until October 21, 2020 (Fig. 1). It is worth mentioning that most of which are located around Qom.
          At the time of the study, southern and eastern provinces of Iran were detected as the most COVID-19 infected regions
          compared to central, northern, and western provinces. Razavi Khorasan, Sistan and Baluchistan, and Kerman were top three
          provinces in terms of lower prevalence of the disease across Iran. Higher urban population of central provinces of Iran could be
          an influential factor related to the higher levels of incidence rates in these areas.

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