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1st Int. Transborder Conf. of the Timor Island: Timor %u2013 Science without borderDili, 7-8 May 2025138Mindfulness-Based Cognitive Therapy Effectively Reduces Depression Levels: A Case Study at Universitas Nusa CendanaIndah Y. P. Ouwpoly, I M. Artawan, Rizky P. Manafe and Nicholas E. Handoyo*Faculty of Medicine and Veterinary Medicine, University of Nusa Cendana, Jl. Adisucipto No 10, Kupang, Nusa Tenggara Timur, Indonesia.*Corresponding author: bahrulilmiabdurahman@gmail.comAbstractMental disorders such as depression, anxiety, and post-traumatic stress disorder (PTSD) remain significant global health challenges, particularly in underserved and transborder regions with limited access to mental health care. Mindfulness-Based Interventions (MBIs), including Mindfulness-Based Stress Reduction (MBSR) and MindfulnessBased Cognitive Therapy (MBCT), have emerged as promising approaches for psychological recovery, potentially inducing neuroplastic changes. Neuroimaging evidence suggests that MBIs modulate brain regions implicated in emotional regulation and stress response; however, a comprehensive synthesis of their neurobiological effects in psychiatric populations is lacking. This systematic review aims to evaluate the impact of MBIs on brain plasticity among individuals with psychiatric disorders and assess their applicability in transborder mental health contexts, such as the Indonesia%u2013Timor Leste border. A systematic search is being conducted across PubMed, Scopus, and Google Scholar for studies published between 2015 and 2025. Inclusion criteria encompass peerreviewed studies involving psychiatric populations, mindfulness-based interventions, and neuroplasticity outcomes assessed through neuroimaging or neurophysiological measures. The review adheres to PRISMA 2020 guidelines, with risk of bias evaluated using the ROBINS-I tool for non-randomized studies. Data extraction and synthesis are managed using Review Manager (RevMan). Preliminary results indicate that MBIs may enhance prefrontal-limbic connectivity and attenuate hyperactivity in limbic structures. These findings underscore the potential of MBIs as low-cost, culturally adaptable interventions to support mental health in resource-limited, cross-border settings.Keywords: mindfulness-based interventions, neuroplasticity, psychiatric disorders, transborder health, neuroimaging, mental health access.