Page 87 - PG 504-theoretical notes-phyto-1-2024-2025..

Clinical pharmacy PharmD program Third level Phytochemistry-1 (PG-504)

1) Sucralfate binds to the surface of ulcers (attaching to exposed proteins) and

coats the ulcer, thus protecting ulcer surface from further injury by acid and

pepsin.

2) Sucralfate directly inhibits pepsin in the presence of stomach acid.

3) Sucralfate binds bile salts coming from the liver via the bile thus protecting

the stomach lining from injury caused by the bile acids.

4) Sucralfate may increase prostaglandin production, and prostaglandins are

known to protect the lining of the stomach.

5) It has no anticoagulant action.

Uses:

Sucralfate is used for the treatment of peptic ulcer disease and to prevent

recurrent ulcers after healing of the ulcer has been achieved. It also has been used
to relieve or prevent the ulcers caused by nonsteroidal anti-inflammatory drugs

(NSAIDs) and the treatment of patients with gastro esophageal reflux disease.

• As compared to ranitidine and cimetidine, sucralfate has the following

characteristics:

1) The short-term healing of duodenal ulcers is the same for the three compounds.

2) Sucralfate-treated patients have a lower recurrence rate of duodenal ulceration

after healing when compared with cimetidine and the recurrence rate is not

connected with the presence or absence of Campylobacter pylori.

2. Sucralose

▪ A trichloro derivative of galacto-sucrose, is named sucralose.

▪ 1', 4, 6'-Trichlorogalactosucrose.

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