Page 32 - Human Umbilical Cord Mesenchymal Stem Cells

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Table 4. Clinical Studies of Mesenchymal Stem Cell-Based Therapy for Chronic Wounds
in the Literature
Wound Investigator Source Delivery Phase Outcome Ref.
LEU Lafosse et al. (2015) AT Local implantation in a CR Improved dermal 146
collagen matrix angiogenesis and
remodeling
Moon et al. (2019) AT Local implantation in a RCT Higher rate of complete 153
hydrogel sheet wound closure; reduced
Kaplan-Meier median time
to complete closure
Falanga et al. (2007) BM Local implantation in a fibrin CR Wounds healed within 20 145
gel weeks
Dash et al. (2009) BM Local delivery RCT Reduced ulcer size 150
Lu et al. (2011) BM Local injection RCT Promoted foot ulcer healing 151
Kirana et al. (2012) BM Intramuscular or intraarterial RCT Improve microcirculation; 152
injection in lower limb support wound healing in
diabetic foot patients
without option of
revascularization
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Benı ´tez-Arvı ´zu et al. BM Local implantation in PRP CR The wound healed; no 175
(2015) complications in 1-year
follow-up
185
Maksimova et al. BM Topical application of cell CR Accelerated
(2017) suspension reepithelialization; all
wounds were closed
successfully
Hashemi et al. Wharton’s Local implantation with CR Significantly decreased 186
(2019) jelly acellular amniotic wound-healing time and
membrane wound size
Qin et al. (2016) Umbilical Endovascular infusion and RCT No serious complications; 147
cord injection around ulcer increased neovessels,
complete or gradual ulcer
healing
Wu et al. (2017) Placenta Deep intramuscular injection Phase 1 No serious adverse events; 148
into the calf of leg with preliminary evidence of
index ulcer ulcer healing within 3
months
Zeng et al. (2017) Placenta Topical application in an CR The ulcer was almost healed; 149
alginate gel no complications; no
recurrence in the follow-up
of 6 months
Radiation Lataillade et al. BM Local injection CR Decreased wound size; almost 154
burns (2007) complete healing 1-month
posttreatment
Bey et al. (2010) BM Local injection CR No recurrence of radiation 155
inflammatory waves in 8-
month follow-up
Portas et al. (2016) BM Local implantation in a fibrin CR Reduced inflammation, 156
matrix improved vasculature and
skin quality
158
Pressure Yoshikawa et al. BM Local implantation in a CR The ulcer almost healed in 9
sores (2008) collagen sponge of 11 pressure sore
patients; the ulcer did not
recur for at least 1-year in
seven patients
CR, case report; LEU, lower extremity ulcers; RCT, randomized controlled trial.

cell (ASC) sheets for the treatment of diabetic foot ulcers. 153 logeneic ASC transplantation. These results revealed that
Thirty patients were recruited in the ASC group, and the ASCs, an important source of MSCs, hold great therapeutic
control group contained 29 patients treated with polyure- potential for diabetic foot ulcers.
thane films. A higher rate of complete wound closure was The inclusion/exclusion criteria of previous clinical trials
recorded in the ASC group, and its Kaplan–Meier median are important basis for establishing standards for patient
time to complete closure was shorter than that of the control selection in future MSC-based wound therapy. For lower
group. There were no serious adverse events related to al- extremity ulcers, the inclusion/exclusion criteria depend