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Umbilical Cord MSC to Support Cell Transplantation 1485

a limited number of human UCB hematopoietic stem 14. Mitchell KE, Weiss ML, Mitchell BM, et al. Matrix cells from
cells in a NOD/SCID transplant model. Furthermore, Wharton’s jelly form neurons and glia. Stem Cells. 2003;21:
we have shown that UC-MSCs can be readily trans- 50-60.
fected with a plasmid-based vector through electropo- 15. Weiss ML, Medicetty S, Bledsoe AR, et al. Human umbilical
ration. These characteristics make UC-MSC ideal cord matrix stem cells: preliminary characterization and effect
of transplantation in a rodent model of Parkinson’s disease.
platform candidates for a broad range of cell-based Stem Cells. 2006;24:781-792.
therapies.
16. Lu LL, Liu YJ, Yang SG, et al. Isolation and characterization of
human umbilical cord mesenchymal stem cells with hematopoi-
esis: supportive function and other potentials. Haematologica.
ACKNOWLEDGMENTS 2006;91:1017-1026.
This work was supported by a grant from the 17. Noort WA, Kruisselbrink AB, In’t Anker P, et al. Mesenchymal
Russo Foundation through the Tufts School of Medi- stem cells promote engraftment of human umbilical cord
cine. We thank Sandra Turcios for assisting in the blood–derived CD34(1) cells in NOD/SCID mice. Exp Hema-
preparation of UC-MSCs. tol. 2002;30:870-878.
18. In’t Anker P, Noort WA, Kruisselbrink AB. Nonexpanded
primary lung and bone marrow–derived mesenchymal cells pro-
mote the engraftment of umbilical cord blood–derived CD34(1)
REFERENCES
cells in NOD/SCID mice. Exp Hematol. 2003;31:881-889.
1. Le Blanc K, Ringden O. Immunobiology of human mesenchy- 19. Vanderson R, Comish J, Sievers EL, et al. Comparison of out-
mal stem cells and future use in hematopoietic stem cell trans- comes of unrelated bone marrow and umbilical cord blood
plantation. Biol Blood Marrow Transplant. 2005;11:321-324. transplants in children with acute leukemia. Blood. 2001;97:
2. Aggarwal S, Pittenger F. Human mesenchymal stem cells 2962-2971.
modulate allogeneic immune cell responses. Blood. 2005;105: 20. Laughlin MJ, Eapen M, Rubinstein P, et al. Outcomes after
1815-1822. transplantation of cord blood or bone marrow from unrelated
3. Horwitz EM, Gordon PL, Koo WK, et al. Isolated allogeneic donors in adults with leukemia. N Eng J Med. 2004;351:
bone marrow–derived mesenchymal cells engraft and stimulate 2265-2275.
growth in children with osteogenesis imperfecta: implications 21. Rocha V, Labopin M, Sanz G, et al. Transplants of umbilical
for cell therapy of bone. Proc Natl Acad Sci U S A. 2002;99: cord blood or bone marrow from unrelated donors in adults
8932-8937. with acute leukemia. N Engl J Med. 2004;351:2276-2285.
4. Hare JM, Dib N, Traverse JH, et al. A double-blind, random- 22. Barker JN, Krepski TP, DeFor TE, et al. Searching for unre-
ized, placebo controlled clinical trial of allogeneic mesenchymal lated donor hematopoietic stem cells: availability and speed of
stem cells for the treatment of patients with acute myocardial in- umbilical cord blood versus bone marrow. Biol Blood Marrow
farction. Abstract 2405-3, presented at the American College of Transplant. 2002;8:257-260.
Cardiology Summit, New Orleans, LA, March 25, 2007. 23. Grewal SS, Barker JN, Davies SM, et al. Unrelated donor hema-
5. Le Blanc K, Rasmusson I, Sundberg B, et al. Treatment of severe topoietic cell transplantation: marrow or umbilical cord blood?
acute graft-versus-host disease with third-party haploidentical Blood. 2003;101:4233-4244.
mesenchymal stem cells. Lancet. 2004;363:1439-1441. 24. Wagner JE, Barker JN, DeFor TE, et al. Transplantation of un-
6. Kebriaei P, Isola L, Bahceci E, et al. Phase II trial of prochymal related donor umbilical cord blood in 102 patients with malig-
(ex-vivo cultured adult human mesenchymal stem cells) and cor- nant and nonmalignant diseases: influence of CD34 cell dose
ticosteroids as primary treatment for acute graft-vs-host disease and HLA disparity on treatment-related mortality and survival.
(aGVHD) [abstract]. Blood. 2006;108:922a. Blood. 2002;100:1611-1618.
7. Campagnoli C, Roberts IA, Kumar S, et al. Identification of 25. McNiece I, Gluckman E, Wagner JE, et al. Ex vivo expansion of
mesenchymal stem/progenitor cells in human first-trimester fe- umbilical cord blood hemopoietic stem and progenitor cells. Exp
tal blood, liver, and bone marrow. Blood. 2001;98:2396-2402. Hematol. 2004;32:409-413.
8. Zhang Y, Lib C, Jianga X, et al. Human placenta–derived mes- 26. Muguruma Y, Yahata T, Miyatake H, et al. Reconstitution of the
enchymal progenitor cells support culture expansion of long- functional human hematopoietic microenvironment derived
1
term culture-initiating cells from cord blood CD34 cells. Exp from human mesenchymal stem cells in the murine bone mar-
Hematol. 2004;32:657-664. row compartment. Blood. 2006;107:1878.
9. Sarugaser R, Lickorish D, Baksh D, et al. Human umbilical cord 27. Shahdadfar A, Fronsdal K, Haug T, et al. In vitro expansion of
perivascular (HUCPV) cells: a source of mesenchymal progeni- human mesenchymal stem cells: choice of serum is a determinant
tors. Stem Cells. 2005;23:220-229. of cell proliferation, differentiation, gene expression, and tran-
10. Miki T, Lehmann T, Hongbo C, et al. Stem cell characteristics scriptome stability. Stem Cells. 2005;23:1357-1366.
of amniotic epithelial cells. Stem Cells. 2005;23:1549-1559. 28. Dimarkis I, Levicar N. Cell culture medium composition and
11. Koegler G, Radke T, Lefort A, et al. Cytokine production and translational adult bone marrow–derived stem cell research.
hematopoiesis supporting activity of cord blood–derived unre- Stem Cells. 2006;24:1407-1408.
stricted somatic stem cells. Exp Hematol. 2005;33:573-583. 29. Sotiropoulou PA, Perez SA, Salagianni M, et al. Characteriza-
12. Carlson BM. Human embryology and developmental biology tion of the optimal culture conditions for clinical scale produc-
rd
(3 ed). 2004. tion of human mesenchymal stem cells. Stem Cells. 2006;24:
13. Wang HS, Hung SC, Peng ST, et al. Mesenchymal stem cells in 462-471.
the Wharton’s jelly of the human umbilical cord. Stem Cells. 30. Vogel JP, Szalay K, Geiger F, et al. Platelet-rich plasma im-
2004;22:1330-1337. proves expansion of human mesenchymal stem cells and retains