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אפרמ יחמצ
                               םיליעי םיילקיפוט םירישכת
                                                    BIO BALANCE
                                                                                                                       PSO & SKIN CONTROL
                                                                                                                                רועה עדמ תורשב
                                                     .

                                                                                                           CONTROL BOTANIPLEX™          	        .
                                   .                     	           ,

                                                                                                 .                  ,
                                                            
      BOTANIPLEX®
                           
           ,
                                                                                                     ,
                                                                                                                                 
      ,
                                                                                                          ,  	 	        	  :                           .
                                                          BARRIER
                                                                                                                                    EXFOLIATING
                                                                                               PSO CONTROL

                                              PROTECTING SERUM
                                                                                                                                  CLEANSING BAR
                                                                                                           .                   ,  	 	            ,     ,




         ,
   	    :
                           	   ,        	                         .

                                                                                             
            ,
                                                                                                                                              .
                       B5 
  	       ,
                                             .
                                        ,

                                                ,
                                                                                                                                     	           (BOTANIPLEX™)
                                                                                            :
                             *
                                                         .(96.5%)
                                          .
                                                                                                     FDA        ,
                                                                                              ,        ,
                                                                                                                                :
              .     24                        •
                                                                   ,

                                                                                                                                        ,
                                          •
                                          
     FDA
                        .

                                                       MULTI CARE
                                                      ,
                                                     MOISTURIZER
                                           .
                                                                                                                                  PSO CONTROL RICH BODY CREAM

            , 
        	   :
                                           .(Transepidermal Water Loss) TEWL
                                                                                                                                           PREBIOTIC
                                                                                                                    ANTI
                                                                                                                                                          ANTI
                                                                                                    6                    58%          .
              ,          ,B5 
  	       ,
                                                                                                                                 ANTI

                                                                                                               INFLAMMATORY
                                                                                                                                                          ITCH
                                                                                                                              ALLERGIC

                                              .       ,(97.8%)
                                                                                                                                         6           83%

                                             ,
                             *
                         .                                      ,SLS ,
                                             ,
         93%                                 •
                                             .
                   25%                       •

                                                                                                    Week 2
                                                                                                                                                           Week 6
                                                                                                                       Week 6
                                                                                                                                                  Week 4
                                                                                                                                         Week 2
              ,     28                         •
                                                                                               0%
                                            .(                          )
                                                                                                                                    0%


                                                                                                                                 % of change (itch level)
                                                                                              -20%
                                                                                                                                  -20%
                                                                                                     -15%

                                                                                            % of change in PASI
                                                                                                                                  -40%
                                                                                                                                         -29%
                                                                                              -40%

                                                                                                              -45%
                                                                                              -60%
                                                                                                                                  -60%
                                                                                                                                                  -54%
                                                                                                                       -58%

                                                                                                                                  -80%
                                                                                              -80%
             	  	    (Corneometer)   	                 28              ,      20        *


                                      	           50                       (Cutometer)
                                                                                                                                                            -83%

                                                                                             -100%
                                                                                                                                  -100%


                                                                                               P<O.01 week 2. week 4. week 6 vs. baseline. N•20
                                                                                                                                  P<0.01 week 2. week 4, week 6 vs. baseline. N•11
                                                                                               PASI = Psoriasis Area Severity lndex
                                                 GENTLE RADIANCE
                                                                                                                                  VAS (Visual Analogue Scale)
                                                FACIAL CLEANSER

                                                   :
                                                   
   	    ,







                  ,CALM


                                                                                                        6


                                                                                                                                                      CLEAR
                              AC - CLEAR SPOT TREATMENT
                                                                                                                                                        CALM
                        CALM INTENSE MOISTURE CREAM         .                               RICH BODY CREAM  Week 4 PSO Body Cream - Clinical Study  .

                                                                       חכומ
                                                                       חכומ
                           SPOT TREATMENT
                          .               3 -                  1



                                           .
                                .SCORAD      "                                                                           
           ,
                                                                                                                                            	        .
                                                                     תירקחמ                                                   ,CLEAR BOTANIPLEX™
                                                                      תירקחמ
                                                                                                                                             - CALM BOTANIPLEX™
                                                   .        2                                                       .
                                                                                                                                       ,
                                                                                                                                .
                       .    	                10
                                                                                                             CALM
                                                                  46%     
                  REPAIR HAND CREAM
                              .                3
                                                                                                 .
                                                                                                 ANTI-BLEMISH                          PURIFYING GEL
           100%                                                                                   FACE CREAM                         FACE CLEANSER
                     Week 1                Week 2                Week 3 88.3                                                                             '
           90%
             0%
                                                                                                                                        
            ,
           80%                                                                                :
                       -3%                           73.3
            -10%                                                                              
       ,                             :
            70%                                                                                    
 	                             E 
  	   ,
         Overall Improvment (%) % Change in SCORAD  -20%  38.3  53.3  -26%  38.32  45    GENTLE SOOTHING WASH
           60%
                                                                                                       CALM BABY
                                                                                                                                        CALM GENTLE
           50%
                                                                                                                                     SOOTHING WASH

                                                                                                     PURIFYING
                                                                                                                                               CLEAR
           40%
                                                                                                 :
                                                                                               CLEANSING BAR
           -30%
                                                                                                                                    SPOT TREATMENT
                                                                                                                                    :

           30%



           20%
           -40%                                                                                          	                                            	   '
                                                                                             :                                                :
            10%     6.66  6.66  6.66                              -46%
                                                                                                          ,                                  12
           -50%                                                                                                                     :
            0%
                                                                                             INSTANST RELIEF GEL
                p<0.01 Week 2, Week 3 vs. baseline, N = 30
           -10%                                                                                            	          '                CALM INTENSE
                                                                                                                                              
       ,2%
                          2
               0 SCORAD at baseline = 42±12  4  5  6    7     8     9    10                                                         MOISTURE CREAM
                                3
                     1
                SCORAD (Scoring of Atopic Dermatitis)
                                     Duration (Day #)
                                                                                                 :
                 Control     Kamedis spot treatment
                                                                                                                                               CLEAR
                                                                                                      Hydroxyphenyl)                 :
                                                                                                                                        PIMPLE PATCH
                                                                                                   Propamidobenzoic

                                                                                                               ,(Acid
                                                                                                                                 ,               .
                                                                                                                                      .
                                                                                                                                    :
                                                                                                                            .
                                                                                                                                                ULTRA
                                                                                                                                      .
                                                                                                                                      HYDRATION GEL
                                                                                                         DRY SKIN                                          '
                                                                                                        FOOT GEL
                                                                                                                                                     אלל
                                                                                                                     '                 		                     אלל
                                                                                                                                          י”ע ץלמומ

                                                                                                                                      :

                                                                                                                                                  םייתוכאלמ םיעבצ

                    10                                                                           :                                 
   	    ,
                                                                                                                                         םיגולוטמרד
                                                                                                              
   	     MUL TI CARE  MOISTURIZER  BIO BALANCE      	                                              ,                                            
          
   	    ,             :                      FACIAL CLEANSER   GENTLE


                                                                                6

                                                                                                                                                                      ,CALM


                                        VAS (Visual Analogue Scale)
                                                                           PASI = Psoriasis Area Severity lndex
                                        P<0.01 week 2. week 4, week 6 vs. baseline. N•11
                                                                           P<O.01 week 2. week 4. week 6 vs. baseline. N•20

                                         -100%
                                                                             -100%

               -83%
                                                                                                                                                                  	  	    (Corneometer)   	                 28              ,      20        *
                                                                             -80%
                                        -80%
                                                   -58%
                        -54%
                                        -60%
                                                                             -60%
                                                            -45%

                                 -29%
                                                                             -40%
                                        -40%
                                                                              % of change in PASI
                                                                      -15%
                                                                             -20%
                                        -20%
                                          % of change (itch level)
                                                                           0%
                                       0%
               Week 6
                                                   Week 6
                                  Week 2
                         Week 4
                                                                      Week 2
                                                             Week 4
                                                                                                                                                                       25%                       •
                                                         PSO Body Cream - Clinical Study
                                                                                                                                                .                                      ,SLS ,
                                                                                                                                             *
                                               6           83%
                                                           INFLAMMA TORY
                                           ALLERGIC
               ITCH
                ANTI
                               PREBIOTIC
                                         ANTI
                                                      ANTI
                                                                                      6                    58%          .
                                                                                                                                                                , 
        	   :
                                                                                                                PSO CONTROL RICH BODY CREAM
                                                                                                                                                                           .
                                                                                                                                                                              ,
                                                                                                                                                  .
                                                                                                                                                                      •
                         .
                                                       ,

                                                                               ,        ,
                                           :
                                                                       FDA        ,
                                                                              :
                                                                                                                                             *

                                                                                                   	           (BOTANIPLEX™)
                                                                                                                                                                        ,
                                                         .
                                                                             
            ,
                                                                                                                                                    B5 
  	       ,

                                                                                                                                                  	   ,        	                         .



                                                               .                   ,  	 	            ,     ,
                                                                               RICH BODY CREAM
                                         CLEANSING BAR
                                                                           PSO CONTROL
                                      EXFOLIA TING
                                                                                                                 BARRIER
                                                                  ,  	 	        	  :                           .
                                                                                            
      ,
                                                                                                              .
                                                                       ,
                                                                                                                                                           
           ,
                                                                         .                  ,
                                                                                            CONTROL BOTANIPLEX™          	        .


                                          רועה עדמ תורשב
                                                   PSO & SKIN CONTROL
                                אפרמ יחמצ
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