Page 8 - Step and repeat document 1
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חכומ
חכומ
SCALP CONTROLOL
P CONTR
SC
AL
,
,
100% .
, ,
100%
.
.
,
63%
,
,63% , .
תירקחמ
תירקחמ
28
. 28 82%
CONTROL BOTANIPLEX™
82%
.
ANIPLEX
T
™
CONTROL BO
11 . ,
.
,
30 .
30
.
0.
0.22
DrynessDryness 0-none0-none
1.61.6 1-mild1-mild
a
2-moderatete
2-moder
3-severee
3-sever
Desqua-Desqua- 0.30.3
ma
mationtion 1.81.8
SCALP C
NOURISHINGNOURISHING SCALP CONTROLONTROL
D
C
0.30.3 CONDITIONERONDITIONER DANDRUFF SHAMPOOANDRUFF SHAMPOO
ItchingItching
1.71.7
.
Redness/Redness/ 0.30.3 D0D0 .
erythemathema 0.80.8
ery
:
D28D28 :
,
00 0.50.5 11 1.51.5 22 86% ,
86%
30
ophotogr
Macr
Macrophotography of the surface of the scalp and hair in alp and hair in 30 .
ace of the sc
f
aphy of the sur
.
Instrumen
zoom 60-times using Aramo SG®ASG 200Famo SG®ASG 200F Instrumental testtal test
zoom 60-times using Ar
, :
,
:
,
,
100%
100%
,
. 28 66% ,
.
28
66%
SCALP C
Erythemathema Desquamationtion 22 SCALP CONTROLONTROL
Desquama
Ery
44 44 SCALP LOTIONTION
O
SCALP L
33 33 33
33 33
22
22 22
1.51.5 :
:
11 11 11 11
,
,
11 11 , ,
0.40.4 11 0.50.5 0.50.5
B
0.60.6 0.30.3 0.22 0.30.3 B
0.
00 00 00 00 00
D0D0 D7D7 D14D14 D28D28 D0D0 D7D7 D14D14 D28D28
MaxMax MeanMean MaxMax MeanMean MinMin
,
-
te, 3-sever
,
22
0-none, 1-mild, 2-moder
0-none, 1-mild, 2-moderate, 3-severee -
, 28 , 22 * *
28
a
100%
D
ANDRUFF
.
.100% * DANDRUFF SHAMPOOOO
*
SHAMP
,
,
,
,
םיטפלוס אלל
םיטפלוס אלל
.
.
SLS, SLES :גוסמ
28 . SLS, SLES :גוסמ
28
.
* *
CALM
SEBO CONTR OL
T-ZONE CREAM חכומ
T ZONE
.
,
CALM INTENSE MOISTURE CREAM תירקחמ CALM INTENSE MOISTURE CREAM חכומ
4
.
2
חכומ
2-12
.
61% , 39%
3 CONTROL BOTANIPLEX™
. ,
77%
.1
. 50%
N=99 תירקחמ .2 תירקחמ
62%
31%
Highly significant e ect of TOPIC Cream on BSA reduction
100% as compared to placebo and comparator T ZONE T ZONE
93 95
90 89 CREAM CLEANSER
90% 85 Treatment Comparator
80 83 81
80% 76 78 100% 100%
Moderate severity Children with mild-moderate severity
,
70
BSA: Min 15% - Max 30%, 62 69 BSA: Min 0.4% - Max 30%, Average : 90%
90%
70%
% of improvment 60% Start Week 1 Week 2 Week 4 54 2 Start Week 1 Week 2 Week 4 Oleanolic acid ,
77% 60%
BSA = 11.0% at baseline
Average 20.2% at baseline
:
80%
80%
58
70%
70%
50%
60%
0
40%
50%
30%
40%
-2 Subjects 50% Subjects 40% 50%
20% 0 30% 30%
-4 20% 20%
10%
10% 10%
0%
-2
-6 ISGA Desquamation Erythema Induration Pruritus 0% 0%
Week 2 Week 4 Week 6 Week 2 Week 4 Week 6
Reduction in BSA (%) -10 53% Improvement Reduction in BSA (%) -4 lmproved > 3 points Stable (change within ±3 points)
VAS (Visual Analogue Scale - 10 points)
p<0.005 week 2, week 4, week 6 vs. baseline, N=24
4 Weeks
-8
2 Weeks
6 Weeks
ISGA = Investigator’s Static Global Assessment
SCORAD
100%
-6
-12
-14 -8 80%
73% Improvement 60% 62%
-16 Subject
-10 40%
-18
20% 31%
-12
Treatment Comparator
0% י”ע ץלמומ אלל אלל
SCORAD (Scoring of Atopic Dermatitis)
BSA (Body Surface Area - percent a ected) Placebo Comparator Treatment
םייתוכאלמ םיעבצ
6 Subjects with > 75% improvement in SCORAD SubjectS with < 75% improvement in SCORAD
םיגולוטמרד םינבראפ
