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אפרמ יחמצ
 םיליעי םיילקיפוט םירישכת
                                   PSO & SKIN CONTROL
 BIO BALANCE
                                            רועה עדמ תורשב
                                        .

                       CONTROL BOTANIPLEX™          	        .
                    .                     	           ,

                 
      BOTANIPLEX®
             .                  ,
       
           ,
                 ,
                                              
      ,
                      ,  	 	        	  :                           .
                                                EXFOLIATING
 BARRIER
           PSO CONTROL

 PROTECTING SERUM
                                              CLEANSING BAR
                       .                   ,  	 	            ,     ,


  ,
   	    :


   	   ,        	                         .

  .
 B5 
  	       ,
                                                          .
         
            ,
                    ,
                                                 	           (BOTANIPLEX™)
  ,

        :
 *
             .(96.5%)
 .
                 FDA        ,
                                            :
          ,        ,
 .     24                        •
                ,

                                                    ,
                    •
         
     FDA
 .

 MULTI CARE
                              ,
 MOISTURIZER
                       .
                                              PSO CONTROL RICH BODY CREAM
  , 
        	   :

  .(Transepidermal Water Loss) TEWL
                                             ANTI
                                                                      ANTI

                6                    58%          .
                                ANTI
        ,          ,B5 
  	       ,
                                                       PREBIOTIC
                                          ALLERGIC
                           INFLAMMATORY
                                                                      ITCH

  .       ,(97.8%)

                                                     6           83%
  ,
 *
 .                                      ,SLS ,
  ,
   93%                                 •
  .
         25%                       •

                Week 2
                                                                        Week 6
                                   Week 6
                                                     Week 2
                                                              Week 4
        ,     28                         •
  .(                          )
           0%
                                                0%


                                             % of change (itch level)
                                              -20%
          -20%
                 -15%

        % of change in PASI
                                                     -29%
          -40%
                                              -40%

                          -45%
          -60%
                                              -60%
                                                              -54%
                                    -58%

                                              -80%
          -80%
   	  	    (Corneometer)   	                 28              ,      20        *


                  	           50                       (Cutometer)
                                                                        -83%

         -100%
                                              -100%


           P<O.01 week 2. week 4. week 6 vs. baseline. N•20
                                              P<0.01 week 2. week 4, week 6 vs. baseline. N•11
                                              VAS (Visual Analogue Scale)
           PASI = Psoriasis Area Severity lndex
  GENTLE RADIANCE
 FACIAL CLEANSER

  :
 
   	    ,







        ,CALM




                    6
                                                                  CLEAR
 AC - CLEAR SPOT TREATMENT
                                                                    CALM
 CALM INTENSE MOISTURE CREAM  .                   RICH BODY CREAM Week 4 PSO Body Cream - Clinical Study  .

 חכומ
 חכומ
  SPOT TREATMENT
 .               3 -                1



 .
 .SCORAD      "                      
           ,
                                                        	        .
 תירקחמ
                                      תירקחמ            ,CLEAR BOTANIPLEX™
                                                         - CALM BOTANIPLEX™
 .        2                     .
                                                   ,
                                            .
 .    	                10
                         CALM
 46%     
     REPAIR HAND CREAM
 .                3
              .
             ANTI-BLEMISH                          PURIFYING GEL
 100%         FACE CREAM                         FACE CLEANSER
 Week 1  Week 2  Week 3 88.3                                               '
 90%
 0%
                                                    
            ,
 80%      :
 -3%  73.3
 -10%     
       ,                             :
 70%           
 	                             E 
  	   ,
 Overall Improvment (%) % Change in SCORAD  40%  38.3  53.3  -26%  38.32  45  GENTLE SOOTHING WASH
 60%
                   CALM BABY
                                                    CALM GENTLE
 -20%
                                                 SOOTHING WASH
 50%

                 PURIFYING
                                                           CLEAR
             :
                                                SPOT TREATMENT
           CLEANSING BAR
 -30%
                                                 :

 30%



 20%
 -40%                	                                            	   '
          :                                                :
 10%  6.66  6.66  6.66  -46%
                      ,                                  12
 0%
 -50%                                           :
         INSTANST RELIEF GEL
 p<0.01 Week 2, Week 3 vs. baseline, N = 30
 -10%                  	          '                 CALM INTENSE
                                                          
       ,2%
 1
 0 SCORAD at baseline = 42±12  4  5  6  7  8  9  10                    MOISTURE CREAM
 2
 3
 SCORAD (Scoring of Atopic Dermatitis)
 Duration (Day #)
             :
 Control  Kamedis spot treatment
                                                           CLEAR
                  Hydroxyphenyl)                 :
                                                    PIMPLE PATCH
               Propamidobenzoic

                           ,(Acid
                                             ,               .
                                                  .
                                                :
                                         .
                                                            ULTRA
                                                  .
                                                  HYDRATION GEL
                     DRY SKIN                                          '
                    FOOT GEL
                                                                 אלל
                                 '                 		                     אלל
                                                      י”ע ץלמומ

                                                  :

      10             :                         
   	    ,
                                                              םייתוכאלמ םיעבצ

                                                     םיגולוטמרד
                          
   	     MUL TI CARE  MOISTURIZER  BIO BALANCE      	                                              ,                                            
          
   	    ,             :                      FACIAL CLEANSER   GENTLE RADIANCE   ,                        PROTECTING SERUM

        6


                                                                                  ,CALM


 PASI = Psoriasis Area Severity lndex
 VAS (Visual Analogue Scale)
 P<O.01 week 2. week 4. week 6 vs. baseline. N•20
 P<0.01 week 2. week 4, week 6 vs. baseline. N•11

 -100%
 -100%

 -83%
                                                                              	  	    (Corneometer)   	                 28              ,      20        *
 -80%
 -80%
 -58%
 -54%
 -60%
 -60%
 -45%

 -40%
 -40%
 -29%
 % of change in PASI
 -15%
 -20%
 -20%
 % of change (itch level)
 0%
 0%
 Week 4
 Week 4
 Week 2
 Week 2
 Week 6
 Week 6
                                                                                   25%                       •
 PSO Body Cream - Clinical Study
                                                            .                                      ,SLS ,
                                                         *
        6           83%
 INFLAMMA TORY
 ALLERGIC
 ITCH
 ANTI
 PREBIOTIC
 ANTI
 ANTI
         6                    58%          .
                                                                            , 
        	   :
                                     PSO CONTROL RICH BODY CREAM
                                                                                       .
                                                                                          ,
                                                              .
                                                                                  •
 .
           ,

  ,        ,
 :
  FDA        ,
 :
                                                         *

                                	           (BOTANIPLEX™)
                                                                                    ,
 
            ,
               .
                                                                B5 
  	       ,

                                                               	   ,        	                         .



 .                   ,  	 	            ,     ,
 CLEANSING BAR
 RICH BODY CREAM
 EXFOLIA TING
                             BARRIER
 PSO CONTROL
  ,  	 	        	  :                           .
                           
      ,
                          .
  ,
 .                  ,
               CONTROL BOTANIPLEX™          	        .


 רועה עדמ תורשב
 PSO & SKIN CONTROL
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