Page 5 - Step and repeat document 1
P. 5
SEBO CONTR
OL
CALM
חכומ
T-ZONE CREAM
T ZONE
.
,
CALM INTENSE MOISTURE CREAM
CALM INTENSE MOISTURE CREAM
4
.
3
חכומ
חכומ
2
2-12
.
61% , 39%
CONTROL BOTANIPLEX™
77%
.1
. ,
50%
.
תירקחמ
תירקחמ
.2
N=99
62%
31%
Highly significant e ect of TOPIC Cream on BSA reduction
100%
as compared to placebo and comparator
T ZONE
T ZONE
95
90
CLEANSER
CREAM
89
90%
Comparator
Treatment
85
83
80
100%
100%
80%
78
76
Children with mild-moderate severity
Moderate severity
,
90%
BSA: Min 0.4% - Max 30%, Average
70
90%
BSA: Min 15% - Max 30%,
69
70%
% of improvment
BSA = 11.0% at baseline
Average 20.2% at baseline
62
80%
80%
58
60%
Oleanolic acid ,
54
77%
70%
70%
Week 1
Start
Week 4
Week 2
Week 4
Week 2
Week 1
Start
50%
60%
60%
Subjects
Subjects
0
2
40%
50%
50%
50%
30%
40%
40%
-2
20%
30%
0
30%
20%
20%
-4
10%
10%
10%
0%
-2
Pruritus
Induration
Erythema
Desquamation
ISGA
0%
0%
-6
Week 2
Week 2
Week 6
Week 4
Week 6
Week 4
Reduction in BSA (%)
Reduction in BSA (%)
VAS (Visual Analogue Scale - 10 points)
p<0.005 week 2, week 4, week 6 vs. baseline, N=24
2 Weeks
6 Weeks
4 Weeks
-8
ISGA = Investigator’s Static Global Assessment
-4
lmproved > 3 points Stable (change within ±3 points)
-10
53% Improvement
100%
-6
-12
80%
-8
-14
60%
Subject
73% Improvement
62%
-16
-10
40%
-18
31%
20%
-12
Comparator
אלל
אלל
0%
י”ע ץלמומ
SCORAD (Scoring of Atopic Dermatitis)
Treatment
Placebo
BSA (Body Surface Area - percent a ected)
Comparator
Subjects with > 75% improvement in SCORAD SubjectS with < 75% improvement in SCORAD
6
םייתוכאלמ םיעבצ
םיגולוטמרד
םינבראפ
CALM
AC - CLEAR SPOT TREATMENT
CALM INTENSE MOISTURE CREAM 93 81 תירקחמ : Treatment SCORAD : CLEAR
חכומ
חכומ
. 3 -
SPOT TREATMENT 1
.
.SCORAD "
,
.
תירקחמ
תירקחמ ,CLEAR BOTANIPLEX™
- CALM BOTANIPLEX™
. 2 .
,
.
. 10
CALM
46%
REPAIR HAND CREAM
. 3
.
ANTI-BLEMISH PURIFYING GEL
100% FACE CREAM FACE CLEANSER
Week 1 Week 2 Week 3 88.3 '
90% 0%
,
80% :
-3% 73.3
-10%
, :
70%
E
,
Overall Improvment (%) % Change in SCORAD 40% 38.3 53.3 -26% 38.32 45 GENTLE SOOTHING WASH SPOT TREATMENT
60%
CALM BABY
CALM GENTLE
-20%
50%
SOOTHING WASH
PURIFYING
CLEAR
:
-30%
CLEANSING BAR
:
30%
20%
-40% '
: :
10% 6.66 6.66 6.66 -46%
, 12
0%
-50% :
INSTANST RELIEF GEL
p<0.01 Week 2, Week 3 vs. baseline, N = 30
-10% ' CALM INTENSE
,2%
2
1
0 SCORAD at baseline = 42±12 4 5 6 7 8 9 10 MOISTURE CREAM
3
SCORAD (Scoring of Atopic Dermatitis)
Duration (Day #)
:
Control Kamedis spot treatment
CLEAR
Hydroxyphenyl) :
PIMPLE PATCH
Propamidobenzoic
,(Acid
, .
.
:
.
ULTRA
.
HYDRATION GEL
DRY SKIN '
FOOT GEL
אלל
' אלל
י”ע ץלמומ
:
םייתוכאלמ םיעבצ
10 :
,
םיגולוטמרד
83 N=99 Induration Start Placebo 78 2 0 -8 -6 -4 -2 BSA = 11.0% at baseline BSA: Min 0.4% - Max 30%, Average Children with mild-moderate severity 2 Weeks Reduction in BSA (%) -10 69 .
םינבראפ
םיגולוטמרד
םייתוכאלמ םיעבצ
6
Subjects with > 75% improvement in SCORAD SubjectS with < 75% improvement in SCORAD
Treatment
BSA (Body Surface Area - percent a ected)
Comparator
SCORAD (Scoring of Atopic Dermatitis)
י”ע ץלמומ
0%
אלל
אלל
Treatment
Comparator
-12
20%
31%
40%
62%
73% Improvement
Subject
60%
80%
-12
100%
SCORAD
53% Improvement
lmproved > 3 points Stable (change within ±3 points)
ISGA = Investigator’s Static Global Assessment
6 Weeks
4 Weeks
-8
p<0.005 week 2, week 4, week 6 vs. baseline, N=24
VAS (Visual Analogue Scale - 10 points)
Reduction in BSA (%)
Week 2
Week 2
Week 6
Week 4
Week 6
Week 4
0%
0%
-6
Desquamation
Pruritus
0%
10%
10%
10%
-4
20%
20%
20%
30%
30%
-2
40%
40%
30%
50%
50%
50%
40%
0
Subjects
Subjects
60%
60%
50%
Week 1
Week 2
Week 1
Week 2
Week 4
70%
70%
77%
Oleanolic acid ,
60%
80%
80%
62
:
:
Average 20.2% at baseline
70%
90%
BSA: Min 15% - Max 30%,
90%
,
Moderate severity
76
80%
100%
100%
81
Comparator
Treatment
90%
89
CLEANSER
CREAM
90
93
95
as compared to placebo and comparator
T ZONE
100%
T ZONE
Highly significant e ect of TOPIC Cream on BSA reduction
31%
62%
.2
תירקחמ
תירקחמ
50%
. ,
77%
.1
CONTROL BOTANIPLEX™
.
61% , 39%
2-12
חכומ
חכומ
תירקחמ
2
3
.
CALM INTENSE MOISTURE CREAM
CALM INTENSE MOISTURE CREAM
.
,
T ZONE
חכומ
SEBO CONTROL
CALM
