Page 10 - Step and repeat document 1

CALM

SEBO CONTR OL
חכומ
T-ZONE CREAM

T ZONE

.
,
CALM INTENSE MOISTURE CREAM תירקחמ CALM INTENSE MOISTURE CREAM חכומ
4
.
חכומ
2
2-12
.
61% , 39%
3 CONTROL BOTANIPLEX™
. ,
77%

.1
. 50%
N=99 תירקחמ .2 תירקחמ

62%
31%
Highly significant e ect of TOPIC Cream on BSA reduction
100% as compared to placebo and comparator T ZONE T ZONE
93 95
90 89 CREAM CLEANSER
90% 85 Treatment Comparator
83
80 81
80% 76 78 100% 100%
Moderate severity Children with mild-moderate severity
,
90%
70
90%
BSA: Min 15% - Max 30%, 62 69 BSA: Min 0.4% - Max 30%, Average : :
70%
% of improvment 60% Start Week 1 Week 2 Week 4 2 Start Week 1 Week 2 Week 4 Oleanolic acid ,
77% 60%
BSA = 11.0% at baseline
Average 20.2% at baseline
80%
80%
58
54
70%
70%
50%
60%
0
40%
30%
40%
40%
-2 Subjects 50% Subjects 50% 50%
20% 0 30% 30%
-4
10% 20% 20%
10% 10%
0%
-2
-6 ISGA Desquamation Erythema Induration Pruritus 0% 0%
Week 2 Week 4 Week 6 Week 2 Week 4 Week 6
Reduction in BSA (%) -10 53% Improvement Reduction in BSA (%) -4 lmproved > 3 points Stable (change within ±3 points)
VAS (Visual Analogue Scale - 10 points)
p<0.005 week 2, week 4, week 6 vs. baseline, N=24
-8
2 Weeks
6 Weeks
4 Weeks
ISGA = Investigator’s Static Global Assessment
SCORAD
-6
100%
-12
80%
-14 -8
73% Improvement 60% 62%
-16 Subject
-10 40%
-18
20% 31%
-12
Treatment Comparator
0% י”ע ץלמומ אלל אלל
SCORAD (Scoring of Atopic Dermatitis)
BSA (Body Surface Area - percent a ected) Placebo Comparator Treatment
6 Subjects with > 75% improvement in SCORAD SubjectS with < 75% improvement in SCORAD
םייתוכאלמ םיעבצ
םיגולוטמרד
םינבראפ
CALM
AC - CLEAR SPOT TREATMENT
CALM INTENSE MOISTURE CREAM חכומ CLEAR
חכומ
. 3 -
SPOT TREATMENT 1

.
.SCORAD "
,
.
תירקחמ
תירקחמ ,CLEAR BOTANIPLEX™
- CALM BOTANIPLEX™
. 2 .
,
.
. 10
CALM
46%
REPAIR HAND CREAM
. 3
.
ANTI-BLEMISH PURIFYING GEL
100% FACE CREAM FACE CLEANSER
Week 1 Week 2 Week 3 88.3 '
90% 0%

,
80% :
-3% 73.3 :
-10%
70%
, E
,

Overall Improvment (%) % Change in SCORAD 50% 38.3 53.3 -26% 38.32 45 GENTLE SOOTHING WASH SPOT TREATMENT
60%
CALM BABY
CALM GENTLE
-20%
SOOTHING WASH

CLEAR
PURIFYING
40%
-30%
:
CLEANSING BAR
:

30%

20%
-40% '
10% 6.66 6.66 6.66 -46% : :
, 12
0%
-50% :
INSTANST RELIEF GEL
-10% p<0.01 Week 2, Week 3 vs. baseline, N = 30 ' CALM INTENSE

,2%
0 SCORAD at baseline = 42±12 4 5 6 7 8 9 10 MOISTURE CREAM
1
2
3
SCORAD (Scoring of Atopic Dermatitis)
Duration (Day #)
:
Control Kamedis spot treatment
CLEAR
Hydroxyphenyl) :
PIMPLE PATCH
Propamidobenzoic

,(Acid
, .
.
:
.
ULTRA
.
HYDRATION GEL
DRY SKIN '
FOOT GEL
אלל
' אלל
י”ע ץלמומ

:

םייתוכאלמ םיעבצ
10 :
,

םיגולוטמרד

םינבראפ