Page 11 - Step and repeat document 1
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חכומ
חכומ
SC
P CONTR
AL
SCALP CONTROLOL
, ,
,
.
100% .
100%
.
.
,
63%
,63% ,
,
תירקחמ
תירקחמ
.
. 28 82%
28
82%
™
T
ANIPLEX
CONTROL BO
CONTROL BOTANIPLEX™
11
,
.
. ,
30
30
.
.
0.22
0.
0-none0-none
DrynessDryness
1-mild1-mild
1.61.6
2-moder
2-moderatete
3-sever
3-severee
0.30.3
Desqua-Desqua-
mationtion
ma
1.81.8
SCALP C
NOURISHINGNOURISHING
SCALP CONTROLONTROL
C
D
CONDITIONERONDITIONER
DANDRUFF SHAMPOOANDRUFF SHAMPOO
0.30.3
ItchingItching
1.71.7
.
.
0.30.3
Redness/Redness/
D0D0
erythemathema
ery
0.80.8
:
:
D28D28
,
86%
,
11
00
86%
0.50.5
1.51.5
ophotogr
30
Macr
Macrophotography of the surface of the scalp and hair in alp and hair in
30
ace of the sc
aphy of the sur
f
.
.
Instrumental testtal test
zoom 60-times using Aramo SG®ASG 200Famo SG®ASG 200F
Instrumen
zoom 60-times using Ar
:
,
,
,
100%
100%
28
,
. 28 66% ,
.
66%
22
SCALP C
SCALP CONTROLONTROL
Desquamationtion
Ery
Erythemathema
Desquama
44
44
O
SCALP LOTIONTION
SCALP L
33
33
33
33
33
22
22
22
1.51.5
:
:
11
11
,
, ,
,
11
11
11
0.40.4
0.50.5
B
B
0.30.3
0.30.3
0.60.6
0.22
0.
00
00
00
00
00
D0D0
D0D0
D7D7
D28D28
D28D28
D7D7
D14D14
D14D14
MaxMax
MeanMean
MinMin
MaxMax
MeanMean
28
-
, 28 , 22 * *
-
22
a
te, 3-sever
0-none, 1-mild, 2-moderate, 3-severee
,
,
0-none, 1-mild, 2-moder
.
.100% * DANDRUFF SHAMPOOOO
100%
D
ANDRUFF
*
,
,
,
,
םיטפלוס אלל
םיטפלוס אלל
.
.
SLS, SLES :גוסמ
28
28
.
.
* *
CALM
11 11 0.50.5 22 SHAMP a , : , SLS, SLES :גוסמ SEBO CONTR OL
חכומ
T-ZONE CREAM
T ZONE
.
,
CALM INTENSE MOISTURE CREAM תירקחמ CALM INTENSE MOISTURE CREAM חכומ
4
.
חכומ
2
2-12
.
61% , 39%
3 CONTROL BOTANIPLEX™
. ,
77%
.1
. 50%
N=99 תירקחמ .2 תירקחמ
62%
31%
Highly significant e ect of TOPIC Cream on BSA reduction
100% as compared to placebo and comparator T ZONE T ZONE
93 95
90 89 CREAM CLEANSER
90% 85 Treatment Comparator
83
80 81
80% 76 78 100% 100%
Moderate severity Children with mild-moderate severity
,
90%
70
BSA: Min 15% - Max 30%, 62 69 BSA: Min 0.4% - Max 30%, Average : 90%
70%
% of improvment 60% Start Week 1 Week 2 Week 4 54 2 Start Week 1 Week 2 Week 4 Oleanolic acid ,
77% 60%
BSA = 11.0% at baseline
Average 20.2% at baseline
:
80%
80%
58
70%
70%
50%
60%
0
40%
50%
30%
40%
-2 Subjects 40% Subjects 50% 50%
20% 0 30% 30%
-4 20% 20%
10%
10% 10%
0%
-2
-6 ISGA Desquamation Erythema Induration Pruritus 0% 0%
Week 2 Week 4 Week 6 Week 2 Week 4 Week 6
Reduction in BSA (%) -10 53% Improvement Reduction in BSA (%) -4 lmproved > 3 points Stable (change within ±3 points)
VAS (Visual Analogue Scale - 10 points)
p<0.005 week 2, week 4, week 6 vs. baseline, N=24
-8
4 Weeks
2 Weeks
6 Weeks
ISGA = Investigator’s Static Global Assessment
SCORAD
100%
-6
-12
80%
-14 -8
73% Improvement 60% 62%
-16 Subject
-10 40%
-18
20% 31%
-12
Treatment Comparator
0% י”ע ץלמומ אלל אלל
SCORAD (Scoring of Atopic Dermatitis)
BSA (Body Surface Area - percent a ected) Placebo Comparator Treatment
6 Subjects with > 75% improvement in SCORAD SubjectS with < 75% improvement in SCORAD
םייתוכאלמ םיעבצ
םיגולוטמרד
םינבראפ Overall Improvment (%)
םינבראפ
םיגולוטמרד
10
,
:
םייתוכאלמ םיעבצ
:
י”ע ץלמומ
'
אלל
אלל
FOOT GEL
'
DRY SKIN
HYDRATION GEL
.
UL TRA
.
:
.
, .
,(Acid
Propamidobenzoic
PIMPLE PA TCH
Hydroxyphenyl)
:
CLEAR
Kamedis spot treatment
Control
:
Duration (Day #)
SCORAD (Scoring of Atopic Dermatitis)
MOISTURE CREAM
3
6
0
10
7
9
4
2
1
8
5
SCORAD at baseline = 42±12
'
,2%
CALM INTENSE
-10%
p<0.01 Week 2, Week 3 vs. baseline, N = 30
INSTANST RELIEF GEL
0%
:
-50%
,
12
10%
6.66
6.66
6.66
-46%
:
:
-40%
20%
'
30%
:
CLEANSING BAR
SPOT TREA TMENT
-30%
:
38.3
-26%
40%
PURIFYING
CLEAR
38.32
45
SOOTHING WASH
50%
GENTLE SOOTHING WASH
-20%
53.3
CALM GENTLE
CALM BABY
60%
% Change in SCORAD
E
,
70%
-10%
,
:
73.3
-3%
80%
:
,
0%
90%
Week 3 88.3
'
Week 2
Week 1
100%
FACE CREAM
FACE CLEANSER
ANTI-BLEMISH
.
PURIFYING GEL
. 3
REPAIR HAND CREAM
46%
CALM
. 10
.
,
. 2
.
- CALM BOTANIPLEX™
תירקחמ
,CLEAR BOTANIPLEX™
תירקחמ
.
.SCORAD "
,
.
. 3 -
SPOT TREATMENT
חכומ
חכומ
1
CALM INTENSE MOISTURE CREAM
AC - CLEAR SPOT TREATMENT
CLEAR
CALM
