Page 6 - Step and repeat document 1
P. 6
חכומ
חכומ
AL
SCALP CONTROLOL
P CONTR
SC
, ,
,
.
100% .
100%
.
.
,
,
63%
,63% ,
תירקחמ
תירקחמ
. 28 82%
.
28
82%
™
T
ANIPLEX
CONTROL BO
CONTROL BOTANIPLEX™
11
,
. ,
.
30
30
.
.
0.22
0.
0-none0-none
DrynessDryness
1-mild1-mild
1.61.6
2-moderatete
2-moder
3-severee
3-sever
0.30.3
Desqua-Desqua-
mationtion
ma
1.81.8
NOURISHINGNOURISHING
SCALP C
SCALP CONTROLONTROL
C
DANDRUFF SHAMPOOANDRUFF SHAMPOO
D
CONDITIONERONDITIONER
0.30.3
ItchingItching
1.71.7
.
.
0.30.3
D0D0
Redness/Redness/
erythemathema
ery
0.80.8
D28D28
:
:
11
0.50.5
86%
1.51.5
22
00
,
,
86%
aphy of the sur
30
ophotogr
30
f
Macr
Macrophotography of the surface of the scalp and hair in alp and hair in
ace of the sc
.
.
zoom 60-times using Ar
zoom 60-times using Aramo SG®ASG 200Famo SG®ASG 200F
Instrumental testtal test
Instrumen
:
,
,
,
100%
100%
28
.
,
66%
. 28 66% ,
22
SCALP C
SCALP CONTROLONTROL
Desquamationtion
Desquama
Erythemathema
Ery
44
44
O
SCALP L
SCALP LOTIONTION
33
33
33
33
33
22
22
22
1.51.5
:
:
11
11
11
11
,
,
, ,
11
11
11
0.40.4
B
0.50.5
B
0.30.3
0.30.3
0.60.6
0.
0.22
00
00
00
00
00
D0D0
D28D28
D0D0
D14D14
D28D28
D7D7
D14D14
D7D7
MinMin
MaxMax
MaxMax
MeanMean
MeanMean
-
0-none, 1-mild, 2-moder
-
, 28 , 22 * *
,
,
a
22
28
te, 3-sever
0-none, 1-mild, 2-moderate, 3-severee
D
100%
.
.100% * DANDRUFF SHAMPOOOO
*
,
,
,
,
םיטפלוס אלל
םיטפלוס אלל
.
.
SLS, SLES :גוסמ
28
28
.
.
* *
CALM
0.50.5 ANDRUFF SHAMP a , : , SLS, SLES :גוסמ SEBO CONTR OL
חכומ
T-ZONE CREAM
T ZONE
.
,
CALM INTENSE MOISTURE CREAM תירקחמ CALM INTENSE MOISTURE CREAM חכומ
4
.
2
חכומ
2-12
.
61% , 39%
3 CONTROL BOTANIPLEX™
. ,
77%
.1
. 50%
N=99 תירקחמ .2 תירקחמ
62%
31%
Highly significant e ect of TOPIC Cream on BSA reduction
100% as compared to placebo and comparator T ZONE T ZONE
93 95
90 89 CREAM CLEANSER
90% 85 Treatment Comparator
83
80 81
80% 76 78 100% 100%
Moderate severity Children with mild-moderate severity
,
BSA: Min 15% - Max 30%, 62 69 BSA: Min 0.4% - Max 30%, Average : 90%
70
90%
70%
% of improvment 60% Start Week 1 Week 2 Week 4 54 2 Start Week 1 Week 2 Week 4 Oleanolic acid ,
77% 60%
BSA = 11.0% at baseline
Average 20.2% at baseline
:
80%
80%
58
70%
70%
50%
60%
0
40%
50%
30%
40%
-2 Subjects 50% Subjects 40% 50%
20% 0 30% 30%
-4 20% 20%
10%
10% 10%
0%
-2
-6 ISGA Desquamation Erythema Induration Pruritus 0% 0%
Week 2 Week 4 Week 6 Week 2 Week 4 Week 6
Reduction in BSA (%) -10 53% Improvement Reduction in BSA (%) -4 lmproved > 3 points Stable (change within ±3 points)
VAS (Visual Analogue Scale - 10 points)
p<0.005 week 2, week 4, week 6 vs. baseline, N=24
-8
4 Weeks
6 Weeks
2 Weeks
ISGA = Investigator’s Static Global Assessment
SCORAD
-6
100%
-12
80%
-14 -8
73% Improvement 60% 62%
-16 Subject
-10 40%
-18
20% 31%
-12
Treatment Comparator
0% י”ע ץלמומ אלל אלל
SCORAD (Scoring of Atopic Dermatitis)
BSA (Body Surface Area - percent a ected) Placebo Comparator Treatment
6 Subjects with > 75% improvement in SCORAD SubjectS with < 75% improvement in SCORAD
םייתוכאלמ םיעבצ
םיגולוטמרד
םינבראפ % Change in SCORAD Overall Improvment (%)
םינבראפ
םיגולוטמרד
10
,
:
םייתוכאלמ םיעבצ
:
י”ע ץלמומ
'
אלל
אלל
FOOT GEL
'
DRY SKIN
HYDRATION GEL
.
UL TRA
.
:
.
, .
,(Acid
Propamidobenzoic
PIMPLE PA TCH
Hydroxyphenyl)
:
CLEAR
Control
Kamedis spot treatment
:
Duration (Day #)
SCORAD (Scoring of Atopic Dermatitis)
MOISTURE CREAM
8
4
10
3
2
9
6
0
5
1
7
SCORAD at baseline = 42±12
'
,2%
CALM INTENSE
-10%
p<0.01 Week 2, Week 3 vs. baseline, N = 30
INSTANST RELIEF GEL
:
-50%
0%
,
12
10%
6.66
6.66
6.66
-46%
:
:
-40%
20%
'
30%
:
CLEANSING BAR
SPOT TREA TMENT
:
-30%
38.3
-26%
40%
PURIFYING
CLEAR
38.32
45
SOOTHING WASH
50%
GENTLE SOOTHING WASH
-20%
53.3
CALM GENTLE
CALM BABY
60%
E
,
70%
-10%
,
:
73.3
-3%
80%
:
,
0%
90%
Week 3 88.3
'
Week 2
Week 1
100%
FACE CREAM
FACE CLEANSER
ANTI-BLEMISH
PURIFYING GEL
.
. 3
REPAIR HAND CREAM
46%
CALM
. 10
.
,
. 2
.
- CALM BOTANIPLEX™
תירקחמ
,CLEAR BOTANIPLEX™
תירקחמ
.
.SCORAD "
,
.
SPOT TREATMENT
. 3 -
חכומ
חכומ
1
CALM INTENSE MOISTURE CREAM
AC - CLEAR SPOT TREATMENT
CALM
CLEAR
