Page 4 - Bio Rex NONI Book

To provide effective health benefits, the inclusion of high-value fruits in the diet requires high daily dosages,
with consequent elevated intake of highly caloric and glycogenic sugars, and implies a rather significant risk of
allergic reactions in the predisposed adult subjects, or in the immunologically-immature paediatric age. The
same holds true for the first-generation of freeze-dried fruit-based concentrated formulations, which retain
entirely in the final product the load of glycogenic sugars added due to the lyophilization technology. Conversely,
BIO REX® NONI is a minimal-volume-concentrated nutraceutical, obtained through a fully natural - though
carefully technologically-controlled - procedure. The final preparation does not contain the high amounts of
unnecessary nutritional sugars, almost entirely consumed upon fermentation, and therefore can be safely
consumed also by hyperglycaemic or diabetic patients.

BIO REX® NONI is more digestible, bioavailable, directly assimilated and, most importantly, it is safely non-
allergenic. In fact, upon fermentation, all the potentially immunogenic macromolecules are degraded to their
smaller active components, with multiplied health-beneficial efficacy. In addition, this natural technological fruit
processing releases mineral micro-nutrients from their plant - phytate complexes, with resulting increased
absorption from the gastrointestinal tract. Also, this highly bio-active fruit preparation is additionally enriched
with specific anti-oxidants, vitamins and polysaccharide immune-stimulants (cell membranes fragments and
lipo-/glyco-peptide small molecules). Fermentation also enhances the pro-digestive properties of the
preparation through the enriched fermenting agents’ and fruit’s fractions of hydrolytic enzymes, and of the low-
molecular-weight organic mono- and dicarboxylic acid (acetic, citric, malic, glycolic, succinic acids).

The final product BIO REX® NONI is hence a complex mixture of more than 200 natural bio-active compounds,
wholly bio-available, concentrated in 7 grams of gelatin. The product’s content is highly standardized through
a strictly-controlled technological process, so that different batches of BIO REX® NONI do not differ by more
than 5% for every single leading component.

BIO REX® NONI BIOACTIVE INGREDIENTS

In the NONI fruit, around 200 bioactive compounds have been reported. The ripe fruit is especially rich in
proteins and astonishingly rich list of complex plant secondary metabolite structures with specific medicinal
properties. These belong to the main chemical families of glycosilated or aglycone polyphenols, anthraquinones,
bioflavonoids, phenylpropanoids, iridoids, lignans, polyterpenes, phytosterols, sugar-esterified medium and
short-chained fatty acids, mono- and di-glycerides, polysaccharides. As said, fermentation processing pre-digests
the fruit high-weight macromolecular components to their easily absorbable and less caloric break-down
products, whilst preserving and concentrating NONI’s and other fruits’ qualified precious secondary-metabolite
bioactive fractions, which are not substrates of microbial hydrolytic activity.

A large number of these NONI ripe-fruit components, mainly phenolic compounds, organic acids and alkaloids
of biomedical relevance have been identified, classified, and described in terms of chemical structure-biological
activity, by a solid scientific and medical literature in the last two decades. To quote only the most relevant
molecules so far identified in terms of unique health properties, a specific polysaccharide-rich fraction,