Page 8 - Bio Rex NONI Book

POTENT PHYSIOLOGICAL IMMUNE-STIMULATOR WITH DISTINCTIVE

CANCER-PREVENTIVE PROPERTIES

NONI’s cancer chemo-preventive effect has been described in some thirty human and animal model
researches so far. The promotion of these clinical studies was based on the large and solid body of over 300
scientific articles reporting laboratory evidences on the immune-stimulating potency of NONI fruit, namely of
its rich anthraquinone and polyterpenoid fractions. These families of active compounds, sensibly concentrated
in the preparation following fermentation process, are able to affect the modulation of many pathways
distinctive of the human immune anticancer function. A controlled clinical study on heavy smokers has shown
that NONI fruit consumption was able to reduce DNA damage (adducts) in the peripheral blood lymphocytes, a
validated biomarker for the prediction of environmental-driven cancer risk. A further controlled clinical study
was able to demonstrate a consistent decrease of pain perception in advanced cancer patients. NONI was also
found effective in the reduction of advanced gastric cancer in two published patient cases. According to
laboratory cellular tests, NONI offers potential to be used as a chemo-adjuvant, especially for the treatment of
human papilloma-induced cervical cancer.

Several laboratory studies have also shown that NONI not only exerts by itself a significant cytotoxic and
apoptotic effect, but is also able to synergize the therapeutic efficacy of conventional anticancer drugs like
cisplatin or doxorubicin. The cytotoxic effect of Noni juice has been attributed to the unique of chemical
compounds such as damnacanthal and alkaloids.

To the NONI polyphenolic fraction, and especially to the fruit iridoid glycosides, there have been attributed a
multiplicity of effects on the recovery of cell-mediated immunity, suppressed in cancer status, for eg. the
increase of peripheral blood granulocytes, the stimulation of IL-2 production, and of natural killer activity in
cancer-bearing animals.

Beneficial effects are also to be anticipated in the medically-controlled administration to cancer patients,
especially in the early stages, with main beneficial outcomes expected on pain scores, on chemo-/radiotherapy
side-toxicity and tissue damage, especially on liver and kidney damage protection.